Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells.
CAR T cells
CD4 CAR
IL15/IL15sushi
T-cell lymphoma
hematopoietic cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
07
2022
accepted:
23
08
2022
entrez:
29
9
2022
pubmed:
30
9
2022
medline:
1
10
2022
Statut:
epublish
Résumé
T-cell lymphomas are aggressive lymphomas that often resist current therapy options or present with relapsed disease, making the development of more effective treatment regimens clinically important. Previously, we have shown that CD4 CAR can effectively target T-cell malignancies in preclinical studies. As IL-15 has been shown to strengthen the anti-tumor response, we have modified CD4 CAR to secrete an IL-15/IL-15sushi complex. These CD4-IL15/IL15sushi CAR T cells and NK92 cells efficiently eliminated CD4+ leukemic cell lines in co-culture assays. Additionally, CD4-IL15/IL15sushi CAR out-performed CD4 CAR in
Identifiants
pubmed: 36172388
doi: 10.3389/fimmu.2022.997482
pmc: PMC9511023
doi:
Substances chimiques
Interleukin-15
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
997482Informations de copyright
Copyright © 2022 Feng, Xu, Cinquina, Wu, Zhang, Sun, Chen, Tian, Song, Pinz, Wada, Jiang, Hanes, Ma and Zhang.
Déclaration de conflit d'intérêts
YM is a founder of iCell Gene Therapeutics LLC. AC, KP, WM, XJ, WH are employed by iCell Gene Therapeutics LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Arch Dermatol. 2003 Nov;139(11):1433-9
pubmed: 14623703
Blood Adv. 2019 Jul 9;3(13):1970-1980
pubmed: 31266741
Mol Ther. 2019 Jun 5;27(6):1126-1138
pubmed: 31005597
Stem Cell Rev Rep. 2021 Apr;17(2):652-661
pubmed: 33410096
Immunity. 2014 Jul 17;41(1):116-26
pubmed: 25035956
Stem Cell Rev Rep. 2019 Jun;15(3):443-447
pubmed: 30826931
Cancers (Basel). 2020 Nov 30;12(12):
pubmed: 33266177
Blood. 2007 Jun 1;109(11):4655-62
pubmed: 17311990
J Immunol. 2006 Nov 1;177(9):6072-80
pubmed: 17056533
Cancer Immunol Res. 2017 Jul;5(7):571-581
pubmed: 28550091
Lancet Oncol. 2018 May;19(5):694-704
pubmed: 29628312
Arthritis Res Ther. 2011;13(5):R177
pubmed: 22029963
J Clin Oncol. 2021 Oct 20;39(30):3340-3351
pubmed: 34324392
Br J Haematol. 2010 Sep;150(5):565-73
pubmed: 20629661
Lancet Haematol. 2020 Nov;7(11):e816-e826
pubmed: 33091355
Blood. 2014 Sep 4;124(10):1570-7
pubmed: 25006130
J Clin Oncol. 2015 Jan 1;33(1):74-82
pubmed: 25403209
Hematol Oncol Clin North Am. 2019 Feb;33(1):103-120
pubmed: 30497668
Molecules. 2019 May 30;24(11):
pubmed: 31151293
Cancer Immunol Res. 2016 Jan;4(1):49-60
pubmed: 26511282
J Clin Oncol. 2008 Sep 1;26(25):4124-30
pubmed: 18626005
Blood. 1996 Feb 1;87(3):893-9
pubmed: 8562959
Blood. 2017 Jul 20;130(3):285-296
pubmed: 28539325
Cytokine Growth Factor Rev. 2002 Apr;13(2):169-83
pubmed: 11900992
Transfus Med Rev. 2019 Apr;33(2):98-110
pubmed: 30948292
Semin Cancer Biol. 2006 Apr;16(2):137-49
pubmed: 16376101
N Engl J Med. 2020 Feb 6;382(6):545-553
pubmed: 32023374
Cancer Res. 2007 Oct 15;67(20):9945-53
pubmed: 17942927
Blood. 1997 Jun 1;89(11):3909-18
pubmed: 9166827
Cancer Cell. 2012 Nov 13;22(5):645-55
pubmed: 23153537
Immunol Cell Biol. 2019 Aug;97(7):664-674
pubmed: 31009109
AIDS Res Hum Retroviruses. 1997 Jul 20;13(11):933-43
pubmed: 9223409
Front Immunol. 2017 Dec 04;8:1597
pubmed: 29255458
J Am Acad Dermatol. 1996 Feb;34(2 Pt 1):244-52
pubmed: 8642089
J Infect Dis. 2004 Jan 15;189(2):286-91
pubmed: 14722894
J Clin Invest. 2008 Jan;118(1):294-305
pubmed: 18060041
Blood. 2015 Aug 20;126(8):983-92
pubmed: 26056165
Leukemia. 2016 Mar;30(3):701-7
pubmed: 26526988
Blood. 2018 Jun 7;131(23):2515-2527
pubmed: 29463563
Clin Cancer Res. 2019 May 1;25(9):2915-2924
pubmed: 30617136
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7788-E7797
pubmed: 27849617
Am J Hematol. 2017 Jul;92(7):706-715
pubmed: 28516671
Blood. 2016 Jun 16;127(24):2980-90
pubmed: 27118452
PLoS One. 2015 Jun 26;10(6):e0131403
pubmed: 26114883
J Exp Med. 2009 Dec 21;206(13):3015-29
pubmed: 20008522
Leukemia. 2021 Mar;35(3):752-763
pubmed: 32632095
Med Oncol. 2005;22(2):191-4
pubmed: 15965283
Cancers (Basel). 2016 Mar 15;8(3):
pubmed: 26999211
N Engl J Med. 2013 Apr 18;368(16):1509-1518
pubmed: 23527958
Toxicology. 2002 Apr 2;172(3):191-203
pubmed: 11893418
J Clin Oncol. 2013 Jun 1;31(16):1970-6
pubmed: 23610113