Evaluation of gastroesophageal reflux disease and hiatal hernia as risk factors for lobectomy complications.
BMI, body mass index
CI, confidence interval
CT, computed tomography
GERD
GERD, gastroesophageal reflux disease
OR, odds ratio
RBC, red blood cell
atrial arrhythmia
hiatal hernia
lobectomy
lung cancer
postoperative complications
Journal
JTCVS open
ISSN: 2666-2736
Titre abrégé: JTCVS Open
Pays: Netherlands
ID NLM: 101768541
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
09
02
2022
accepted:
31
05
2022
entrez:
29
9
2022
pubmed:
30
9
2022
medline:
30
9
2022
Statut:
epublish
Résumé
Up to 40% of lobectomies are complicated by adverse events. Gastroesophageal reflux disease (GERD) and hiatal hernia have been associated with morbidity across a range of clinical scenarios, yet their relation to recovery from pulmonary resection is understudied. We evaluated GERD and hiatal hernia as predictors of complications after lobectomy for lung cancer. Lobectomy patients at Yale-New Haven Hospital between January 2014 and April 2021 were evaluated for predictors of 30-day postoperative complications, pneumonia, atrial arrhythmia, readmission, and mortality. Multivariable regression models included sociodemographic characteristics, body mass index, surgical approach, cardiopulmonary comorbidities, hiatal hernia, GERD, and preoperative acid-suppressive therapy as predictors. Overall, 824 patients underwent lobectomy, including 50.5% with a hiatal hernia and 38.7% with GERD. The median age was 68 [interquartile range, 61-74] years, and the majority were female (58.4%). At least 1 postoperative complication developed in 39.6% of patients, including atrial arrhythmia (11.7%) and pneumonia (4.1%). Male sex (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.11-2.06, Our findings indicate that hiatal hernia may be a novel risk factor for complications, especially atrial arrhythmia, following lobectomy that should be considered in the preoperative evaluation of lung cancer patients.
Identifiants
pubmed: 36172441
doi: 10.1016/j.xjon.2022.05.017
pii: S2666-2736(22)00243-1
pmc: PMC9510864
doi:
Types de publication
Journal Article
Langues
eng
Pagination
327-345Subventions
Organisme : NIDDK NIH HHS
ID : T35 DK104689
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© 2022 The Author(s).
Références
J Cardiothorac Surg. 2012 Jan 10;7:4
pubmed: 22233837
Ann Thorac Surg. 2017 May;103(5):1566-1572
pubmed: 28215423
Eur Respir J. 2012 Feb;39(2):344-51
pubmed: 21737563
BMJ. 2014 Oct 23;349:g6154
pubmed: 25341679
Eur Respir J. 2016 Sep;48(3):833-42
pubmed: 27174889
Surg Innov. 2017 Apr;24(2):122-132
pubmed: 28128014
Pol J Radiol. 2021 Jan 08;86:e1-e3
pubmed: 33708268
J Clin Gastroenterol. 1984 Oct;6(5):467-70
pubmed: 6501834
Anaesthesia. 2016 Dec;71(12):1424-1430
pubmed: 27666330
World J Gastroenterol. 2014 Jul 28;20(28):9592-9
pubmed: 25071357
Am J Respir Crit Care Med. 2006 May 15;173(10):1161-9
pubmed: 16474029
Ann Thorac Surg. 2010 Aug;90(2):368-74
pubmed: 20667313
J Thorac Cardiovasc Surg. 2013 May;145(5):1312-8
pubmed: 23142119
Nat Rev Cardiol. 2020 Aug;17(8):474-502
pubmed: 32231332
Neurogastroenterol Motil. 2015 Jul;27(7):963-70
pubmed: 25930019
J Thorac Cardiovasc Surg. 2007 Mar;133(3):775-9
pubmed: 17320583
Interact Cardiovasc Thorac Surg. 2017 Feb 1;24(2):260-264
pubmed: 27803121
Respir Med. 2012 Oct;106(10):1463-71
pubmed: 22862997
Surgery. 2019 Aug;166(2):211-217
pubmed: 31202473
Radiol Clin North Am. 2012 Sep;50(5):863-76
pubmed: 22974775
J Thorac Dis. 2017 May;9(5):1289-1294
pubmed: 28616280
Gastroenterology. 2020 Apr;158(5):1250-1261.e2
pubmed: 31866243
Eur J Cardiothorac Surg. 2014 Apr;45(4):652-9; discussion 659
pubmed: 24062351
Am J Surg. 2010 Apr;199(4):558-61
pubmed: 20359574
Ann Thorac Surg. 2016 Apr;101(4):1379-86; discussion 1386-7
pubmed: 26785936
Asian Pac J Cancer Prev. 2014;15(7):3071-4
pubmed: 24815449
Ther Adv Drug Saf. 2018 Nov 19;10:2042098618809927
pubmed: 31019676
CMAJ. 2011 Feb 22;183(3):310-9
pubmed: 21173070
J Korean Med Sci. 2011 Aug;26(8):979-84
pubmed: 21860545
J Atr Fibrillation. 2013 Aug 31;6(2):894
pubmed: 28496881
World J Surg. 2020 Nov;44(11):3952-3959
pubmed: 32681318
J Thorac Cardiovasc Surg. 2011 Jul;142(1):47-52.e3
pubmed: 21683838
PLoS One. 2017 Aug 24;12(8):e0183808
pubmed: 28837700
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
pubmed: 26742998
Ann Thorac Surg. 2014 Jan;97(1):236-42; discussion 242-4
pubmed: 24090577
Am J Cardiol. 2008 Nov 1;102(9):1207-11
pubmed: 18940293
Am Surg. 2018 Jun 1;84(6):978-982
pubmed: 29981634
J Clin Gastroenterol. 2007 Oct;41(9):814-8
pubmed: 17881926
Respir Med. 2015 Oct;109(10):1340-6
pubmed: 26209227
Surg Today. 2000;30(10):879-85
pubmed: 11059726
Eur Surg. 2017;49(5):210-217
pubmed: 29104588
AJR Am J Roentgenol. 1977 Apr;128(4):549-61
pubmed: 403780
J Gastrointest Surg. 2016 Jan;20(1):104-10; discussion 110
pubmed: 26403715
Ann Thorac Surg. 2018 Sep;106(3):902-908
pubmed: 29704479
Ann Epidemiol. 2001 Oct;11(7):477-83
pubmed: 11557179
Ann Thorac Surg. 2012 Feb;93(2):372-9
pubmed: 21945225
Europace. 2017 Jan;19(1):16-20
pubmed: 27247004