Quality assessment in light microscopy for routine use through simple tools and robust metrics.


Journal

The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356

Informations de publication

Date de publication:
07 11 2022
Historique:
received: 15 07 2021
revised: 04 04 2022
accepted: 31 08 2022
entrez: 29 9 2022
pubmed: 30 9 2022
medline: 4 10 2022
Statut: ppublish

Résumé

Although there is a need to demonstrate reproducibility in light microscopy acquisitions, the lack of standardized guidelines monitoring microscope health status over time has so far impaired the widespread use of quality control (QC) measurements. As scientists from 10 imaging core facilities who encounter various types of projects, we provide affordable hardware and open source software tools, rigorous protocols, and define reference values to assess QC metrics for the most common fluorescence light microscopy modalities. Seven protocols specify metrics on the microscope resolution, field illumination flatness, chromatic aberrations, illumination power stability, stage drift, positioning repeatability, and spatial-temporal noise of camera sensors. We designed the MetroloJ_QC ImageJ/Fiji Java plugin to incorporate the metrics and automate analysis. Measurements allow us to propose an extensive characterization of the QC procedures that can be used by any seasoned microscope user, from research biologists with a specialized interest in fluorescence light microscopy through to core facility staff, to ensure reproducible and quantifiable microscopy results.

Identifiants

pubmed: 36173380
pii: 213512
doi: 10.1083/jcb.202107093
pmc: PMC9526251
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : French National Research Agency
ID : ANR-10-INBS-04
Organisme : Centre National de la Recherche Scientifique

Informations de copyright

© 2022 Faklaris et al.

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Auteurs

Orestis Faklaris (O)

Montpellier Ressources Imagerie, Biocampus, University of Montpellier, CNRS, INSERM, Montpellier, France.

Leslie Bancel-Vallée (L)

Montpellier Ressources Imagerie, Biocampus, University of Montpellier, CNRS, INSERM, Montpellier, France.

Aurélien Dauphin (A)

Unite Genetique et Biologie du Développement U934, PICT-IBiSA, Institut Curie, INSERM, CNRS, PSL Research University, Paris, France.

Baptiste Monterroso (B)

Prism, Institut de Biologie Valrose, CNRS UMR 7277, INSERM 1091, University of Nice Sophia Antipolis - Parc Valrose, Nice, France.

Perrine Frère (P)

Plate-forme d'Imagerie de Tenon, UMR_S 1155, Hôpital Tenon, Paris, France.

David Geny (D)

Institut de Psychiatrie Et Neurosciences de Paris, INSERM U1266, Paris, France.

Tudor Manoliu (T)

Gustave Roussy, Université Paris-Saclay, Plate-forme Imagerie et Cytométrie, UMS AMMICa. Villejuif, France.

Sylvain de Rossi (S)

Montpellier Ressources Imagerie, Biocampus, University of Montpellier, CNRS, INSERM, Montpellier, France.

Fabrice P Cordelières (FP)

University of Bordeaux, CNRS, INSERM, Bordeaux Imaging Center, UMS 3420, US 4, Bordeaux, France.

Damien Schapman (D)

Université of Rouen Normandie, INSERM, Plate-Forme de Recherche en Imagerie Cellulaire de Normandie, Rouen, France.

Roland Nitschke (R)

Life Imaging Center and Signalling Research Centres CIBSS and BIOSS, University Freiburg, Freiburg, Germany.

Julien Cau (J)

Montpellier Ressources Imagerie, Biocampus, University of Montpellier, CNRS, INSERM, Montpellier, France.

Thomas Guilbert (T)

Institut Cochin, INSERM (U1016), CNRS (UMR 8104), Universite de Paris (UMR-S1016), Paris, France.

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