Trends of hepatitis B virus genotype distribution in chronic hepatitis B patients in Japan.

Humans Young Adult Aged Hepatitis B virus / genetics Hepatitis B, Chronic / epidemiology Japan / epidemiology DNA, Viral Genotype Hepatitis B
Chronic hepatitis B Genotype Geographical distribution Hepatitis B virus Trend of genotype

Journal

Journal of gastroenterology
ISSN: 1435-5922
Titre abrégé: J Gastroenterol
Pays: Japan
ID NLM: 9430794

Informations de publication

Date de publication:
12 2022
Historique:
received: 03 07 2022
accepted: 07 09 2022
pubmed: 30 9 2022
medline: 18 11 2022
entrez: 29 9 2022
Statut: ppublish

Résumé

Hepatitis B virus (HBV) is one of the most prevalent chronic viral infections that causes chronic hepatitis B (CHB). In Japan, genotypes B and C account for most of acute and chronic cases of hepatitis. However, previous studies showed that the prevalence of genotype A in CHB gradually increased every 5 years. Therefore, we have conducted a nationwide survey to comprehensively investigate the trends of HBV genotype distribution in CHB patients in Japan. 4421 CHB patients were recruited between 2015 and 2016. Clinical characteristics and distribution of CHB patients among different age groups and genotypes in 2015-2016 was compared with those in 2000-2001, 2005-2006, and 2010-2011. The percentages of genotype A, B, C, and D were 4.0, 16.2, 79.1, and 0.7%, respectively. While the overall percentage of CHB patients with genotype A did not change in the past 5 years, CHB with genotype A increased in young adults. On the other hand, the peak distribution of CHB with genotypes B and C, two genotypes with the largest patient population, has shifted to an older age group. In Japan, the peak distribution for CHB with genotypes B and C advanced to an older age group while CHB with genotype A expanded in a younger age group. Given the universal HBV vaccination launch in Japan in 2016, these pre-vaccination survey data provide important baseline information for comparative studies of the impact of universal vaccination on HBV genotypes.

Sections du résumé

BACKGROUND
Hepatitis B virus (HBV) is one of the most prevalent chronic viral infections that causes chronic hepatitis B (CHB). In Japan, genotypes B and C account for most of acute and chronic cases of hepatitis. However, previous studies showed that the prevalence of genotype A in CHB gradually increased every 5 years. Therefore, we have conducted a nationwide survey to comprehensively investigate the trends of HBV genotype distribution in CHB patients in Japan.
METHODS
4421 CHB patients were recruited between 2015 and 2016. Clinical characteristics and distribution of CHB patients among different age groups and genotypes in 2015-2016 was compared with those in 2000-2001, 2005-2006, and 2010-2011.
RESULTS
The percentages of genotype A, B, C, and D were 4.0, 16.2, 79.1, and 0.7%, respectively. While the overall percentage of CHB patients with genotype A did not change in the past 5 years, CHB with genotype A increased in young adults. On the other hand, the peak distribution of CHB with genotypes B and C, two genotypes with the largest patient population, has shifted to an older age group.
CONCLUSIONS
In Japan, the peak distribution for CHB with genotypes B and C advanced to an older age group while CHB with genotype A expanded in a younger age group. Given the universal HBV vaccination launch in Japan in 2016, these pre-vaccination survey data provide important baseline information for comparative studies of the impact of universal vaccination on HBV genotypes.

Identifiants

DOI: 10.1007/s00535-022-01921-4 PMID: 36173513
pubmed: 36173513
doi: 10.1007/s00535-022-01921-4
pii: 10.1007/s00535-022-01921-4
doi:

Substances chimiques

DNA, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

971-980

Subventions

Organisme : Japan Agency for Medical Research and Development
ID : JP20fk0310118
Organisme : Japan Agency for Medical Research and Development
ID : JP21fk0310118h0005
Organisme : Japan Agency for Medical Research and Development
ID : JP22fk0310502h0001
Organisme : Japan Society for the Promotion of Science
ID : JP19K08479

Informations de copyright

© 2022. Japanese Society of Gastroenterology.

Références

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Auteurs

Kazumasa Sakamoto (K)

Department of Gastroenterology, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Kiyoaki Ito (K)

Department of Gastroenterology, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. kito@aichi-med-u.ac.jp.

Hiroshi Yotsuyanagi (H)

Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Hiroshi Yatsuhashi (H)

Clinical Research Center, Department of Hepatology, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.

Yasuhito Tanaka (Y)

Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Shuhei Hige (S)

Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan.

Yasuhiro Takikawa (Y)

Department of Internal Medicine, Iwate Medical University, Iwate, Japan.

Yoshiyuki Ueno (Y)

Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Kazuhide Yamamoto (K)

Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan.

Fumio Imazeki (F)

Safety and Health Organization, Chiba University, Chiba, Japan.

Jun Inoue (J)

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Masayuki Kurosaki (M)

Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Japan.

Takeji Umemura (T)

Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Hidenori Toyoda (H)

Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.

Eiji Mita (E)

Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan.

Kojiro Michitaka (K)

Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.

Tatsuji Maeshiro (T)

Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Norie Yamada (N)

Department of Internal Medicine, Center for Liver Diseases, Seizankai Kiyokawa Hospital, Tokyo, Japan.

Atsushi Suetsugu (A)

Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.

Miwa Kawanaka (M)

Department of General Internal Medicine2, Kawasaki Medical School, Okayama, Japan.

Yuya Seko (Y)

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Kentaro Matsuura (K)

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Akinori Okumura (A)

Department of Gastroenterology, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Yoshitaka Fukuzawa (Y)

Department of Gastroenterology, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Masaya Sugiyama (M)

Department of Viral Pathogenesis and Controls, National Center for Global Health and Medicine, Ichikawa, Japan.

Masashi Mizokami (M)

Genome Medical Sciences Project, National Center for Global Health and Medicine, Ichikawa, Japan.

Masashi Yoneda (M)

Department of Gastroenterology, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

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