Estimation of the firing behaviour of a complete motoneuron pool by combining electromyography signal decomposition and realistic motoneuron modelling.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
15
03
2022
accepted:
08
09
2022
revised:
11
10
2022
pubmed:
30
9
2022
medline:
14
10
2022
entrez:
29
9
2022
Statut:
epublish
Résumé
Our understanding of the firing behaviour of motoneuron (MN) pools during human voluntary muscle contractions is currently limited to electrophysiological findings from animal experiments extrapolated to humans, mathematical models of MN pools not validated for human data, and experimental results obtained from decomposition of electromyographical (EMG) signals. These approaches are limited in accuracy or provide information on only small partitions of the MN population. Here, we propose a method based on the combination of high-density EMG (HDEMG) data and realistic modelling for predicting the behaviour of entire pools of motoneurons in humans. The method builds on a physiologically realistic model of a MN pool which predicts, from the experimental spike trains of a smaller number of individual MNs identified from decomposed HDEMG signals, the unknown recruitment and firing activity of the remaining unidentified MNs in the complete MN pool. The MN pool model is described as a cohort of single-compartment leaky fire-and-integrate (LIF) models of MNs scaled by a physiologically realistic distribution of MN electrophysiological properties and driven by a spinal synaptic input, both derived from decomposed HDEMG data. The MN spike trains and effective neural drive to muscle, predicted with this method, have been successfully validated experimentally. A representative application of the method in MN-driven neuromuscular modelling is also presented. The proposed approach provides a validated tool for neuroscientists, experimentalists, and modelers to infer the firing activity of MNs that cannot be observed experimentally, investigate the neuromechanics of human MN pools, support future experimental investigations, and advance neuromuscular modelling for investigating the neural strategies controlling human voluntary contractions.
Identifiants
pubmed: 36174126
doi: 10.1371/journal.pcbi.1010556
pii: PCOMPBIOL-D-22-00412
pmc: PMC9553065
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1010556Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Neurophysiol. 1998 Aug;80(2):583-93
pubmed: 9705452
Clin Neurophysiol. 2009 May;120(5):947-52
pubmed: 19375385
Acta Anat (Basel). 1955;23(2):127-42
pubmed: 14349537
J Physiol. 1984 Dec;357:453-83
pubmed: 6512700
J Biomech Eng. 2022 Jan 1;144(1):
pubmed: 34251438
J Physiol. 1979 Feb;287:33-43
pubmed: 430414
Clin Neurophysiol. 2015 Dec;126(12):2381-9
pubmed: 25727901
Physiol Rep. 2016 Oct;4(19):
pubmed: 27694526
J Biomech. 2015 Nov 5;48(14):3929-36
pubmed: 26522621
Biosensors (Basel). 2020 Jul 26;10(8):
pubmed: 32722542
Spinal Cord. 2008 Oct;46(10):696-702
pubmed: 18332883
J Neurophysiol. 1993 Apr;69(4):1160-70
pubmed: 8492155
J Neurophysiol. 1993 Dec;70(6):2470-88
pubmed: 8120594
Muscle Nerve. 2005 Apr;31(4):461-7
pubmed: 15685623
PLoS One. 2012;7(12):e52618
pubmed: 23300725
J Appl Physiol (1985). 2021 Feb 1;130(2):342-354
pubmed: 33242301
J Appl Physiol (1985). 1999 Aug;87(2):843-52
pubmed: 10444648
Nature. 1954 May 22;173(4412):971-3
pubmed: 13165697
J Neurophysiol. 1985 May;53(5):1323-44
pubmed: 3839011
J Electromyogr Kinesiol. 2021 Jun;58:102548
pubmed: 33838590
J Physiol. 1974 Jun;239(2):301-24
pubmed: 4137933
Crit Rev Biomed Eng. 1989;17(4):359-411
pubmed: 2676342
J Biomech. 2014 Feb 07;47(3):631-8
pubmed: 24368144
Front Neurol. 2020 Dec 18;11:578559
pubmed: 33408680
J Neurophysiol. 1965 May;28:560-80
pubmed: 14328454
IEEE Trans Biomed Eng. 2016 Oct;63(10):2068-79
pubmed: 27392337
J Appl Physiol (1985). 2011 Aug;111(2):485-94
pubmed: 21596915
Comput Biol Med. 2019 Dec;115:103480
pubmed: 31629271
J Neural Eng. 2008 Jun;5(2):175-84
pubmed: 18441419
J Physiol. 1984 Nov;356:401-31
pubmed: 6520792
J Physiol. 1982 Aug;329:113-28
pubmed: 7143246
J Comp Neurol. 1982 Jul 20;209(1):17-28
pubmed: 7119171
Prog Biophys Biophys Chem. 1957;7:255-318
pubmed: 13485191
Exerc Sport Sci Rev. 2015 Jan;43(1):23-33
pubmed: 25390298
Nat Commun. 2018 Feb 19;9(1):709
pubmed: 29459723
Nat Biomed Eng. 2021 May 31;:
pubmed: 34059810
J Neurophysiol. 2013 Dec;110(11):2592-606
pubmed: 24027105
Acta Physiol Scand. 1985 Mar;123(3):229-35
pubmed: 2932890
PLoS One. 2013;8(2):e56013
pubmed: 23405245
J Physiol. 2001 Apr 1;532(Pt 1):271-81
pubmed: 11283241
J Biomech. 2003 Jun;36(6):765-76
pubmed: 12742444
J Neurophysiol. 1986 May;55(5):947-65
pubmed: 3711974
Brain Res. 2009 Nov 3;1296:225-33
pubmed: 19596283
Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1378-403
pubmed: 15142845
Histochem J. 1983 Feb;15(2):167-78
pubmed: 6343306
J Physiol. 2014 Aug 15;592(16):3427-41
pubmed: 24860172
Sci Rep. 2020 Apr 2;10(1):5834
pubmed: 32242142
Front Neuroinform. 2018 Apr 11;12:15
pubmed: 29695959
Sensors (Basel). 2021 Jul 15;21(14):
pubmed: 34300581
Biol Cybern. 2006 Jul;95(1):1-19
pubmed: 16622699
J Appl Physiol (1985). 2021 Jun 1;130(6):1798-1813
pubmed: 33955258
J Physiol. 1998 Nov 15;513 ( Pt 1):295-305
pubmed: 9782179
J Physiol. 2019 Apr;597(7):1873-1887
pubmed: 30727028
J Physiol. 2016 Oct 1;594(19):5491-505
pubmed: 27151459
J Electromyogr Kinesiol. 2020 Aug;53:102426
pubmed: 32438235
Physiol Meas. 2014 Jul;35(7):R143-65
pubmed: 24943407
Elife. 2022 Jul 18;11:
pubmed: 35848819
J Neurophysiol. 1998 Aug;80(2):572-82
pubmed: 9705451
J Appl Physiol (1985). 2010 Jun;108(6):1550-62
pubmed: 20360437
Brain Res. 1984 Jul 30;307(1-2):167-79
pubmed: 6466992
J Exp Biol. 1985 Mar;115:105-12
pubmed: 3161974
Physiology (Bethesda). 2020 Jan 1;35(1):31-39
pubmed: 31799904
Wiley Interdiscip Rev Syst Biol Med. 2019 Nov;11(6):e1457
pubmed: 31237041
J Neurophysiol. 1981 Dec;46(6):1326-38
pubmed: 6275043
IEEE Trans Rehabil Eng. 1997 Jun;5(2):179-94
pubmed: 9184904
J Neurophysiol. 1986 Apr;55(4):619-34
pubmed: 3701396
Neural Comput. 2011 Nov;23(11):2833-67
pubmed: 21851282
Exp Brain Res. 1993;93(3):492-8
pubmed: 8519338
J Biomech. 1996 Nov;29(11):1455-62
pubmed: 8894926
J Physiol. 1977 Jan;264(3):673-93
pubmed: 845820
J Biomech. 1981;14(11):747-58
pubmed: 7334035
J Comp Neurol. 1988 Dec 1;278(1):103-20
pubmed: 3209749
J Neurophysiol. 2020 Apr 1;123(4):1380-1391
pubmed: 32073942
J Neural Eng. 2016 Aug;13(4):046002
pubmed: 27187214
J Neurophysiol. 1974 Nov;37(6):1338-49
pubmed: 4436704
J Neurophysiol. 1975 Jul;38(4):933-46
pubmed: 1159473
J Neurophysiol. 2012 Jan;107(2):666-76
pubmed: 21994258
J Neurophysiol. 2011 Nov;106(5):2688-97
pubmed: 21795617
Sci Rep. 2017 Oct 18;7(1):13465
pubmed: 29044165
J Physiol. 1989 Jun;413:255-69
pubmed: 2600850
Biol Cybern. 1977 Jan 20;25(2):103-19
pubmed: 836914
Exp Brain Res. 1991;84(1):210-8
pubmed: 1855559
PLoS One. 2013;8(2):e53425
pubmed: 23405069
J Biomech. 2016 Oct 3;49(14):3375-3380
pubmed: 27614612
IEEE Trans Neural Netw. 2004 Sep;15(5):1063-70
pubmed: 15484883
J Physiol. 2018 Jul;596(14):2643-2659
pubmed: 29726002
PLoS One. 2014 Aug 01;9(8):e95454
pubmed: 25083794
J Comp Neurol. 1981 Nov 10;202(4):571-83
pubmed: 7298916
J Neurophysiol. 1987 Apr;57(4):1227-45
pubmed: 3585462
Med Sci Sports Exerc. 2010 Sep;42(9):1644-50
pubmed: 20142771
J Neurophysiol. 2010 Aug;104(2):1034-46
pubmed: 20554838
J Exp Biol. 2017 May 1;220(Pt 9):1643-1653
pubmed: 28202584
J Clin Neuromuscul Dis. 2002 Jun;3(4):139-42
pubmed: 19078670
PLoS Comput Biol. 2017 Jun 2;13(6):e1005581
pubmed: 28574981
J Physiol. 1987 Oct;391:561-71
pubmed: 3443957
Muscle Nerve. 2014 Dec;50(6):884-93
pubmed: 25186553
Eur J Neurosci. 2021 Mar;53(6):1938-1949
pubmed: 33377245
Science. 1966 Jun 17;152(3729):1637-40
pubmed: 5936887
Science. 1957 Dec 27;126(3287):1345-7
pubmed: 13495469
Compr Physiol. 2012 Oct;2(4):2629-82
pubmed: 23720261
Am J Phys Med. 1959 Apr;38(2):65-78
pubmed: 13637190
J Neural Eng. 2016 Apr;13(2):026027
pubmed: 26924829
Muscle Nerve. 1988 Feb;11(2):136-45
pubmed: 3343989
BMC Musculoskelet Disord. 2020 Oct 15;21(1):682
pubmed: 33059684
Can J Appl Physiol. 1997 Dec;22(6):585-97
pubmed: 9415831
J Physiol. 1993 Apr;463:307-24
pubmed: 8246185
J Neurophysiol. 2018 Oct 1;120(4):1973-1987
pubmed: 30020845
Exerc Sport Sci Rev. 2021 Jul 1;49(3):179-187
pubmed: 33927163
J Appl Physiol (1985). 2014 Jan 15;116(2):140-8
pubmed: 24311748
J Neurophysiol. 2017 Mar 1;117(3):1171-1184
pubmed: 28053245
J Comput Neurosci. 2008 Dec;25(3):520-42
pubmed: 18506610
Physiology (Bethesda). 2019 Jan 1;34(1):5-13
pubmed: 30540233
J Neurophysiol. 1965 May;28(3):599-620
pubmed: 5835487
Biophys J. 2000 Jul;79(1):314-20
pubmed: 10866957
Front Neurol. 2020 Nov 06;11:578504
pubmed: 33240204
PLoS Comput Biol. 2018 Jul 26;14(7):e1006223
pubmed: 30048444
Brain Res. 1981 Dec 14;229(1):193-6
pubmed: 7306807
Exp Brain Res. 1997 Mar;114(1):117-23
pubmed: 9125456