Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL.
Cardiometabolic and pulmonary phenotypes
Genetic correlation
Mendelian randomization
Obstructive sleep apnoea
Polygenic risk score
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
11
05
2022
revised:
24
08
2022
accepted:
08
09
2022
pubmed:
30
9
2022
medline:
19
10
2022
entrez:
29
9
2022
Statut:
ppublish
Résumé
Obstructive Sleep Apnoea (OSA) often co-occurs with cardiometabolic and pulmonary diseases. This study is to apply genetic analysis methods to explain the associations between OSA and related phenotypes. In the Hispanic Community Healthy Study/Study of Latinos, we estimated genetic correlations ρ The dataset included 11,155 participants, 31.03% with OSA. 22 phenotypes were genetically correlated with REI. 10 PRSs covering obesity and fat distribution (BMI, WHR, WHRadjBMI), blood pressure (DBP, PP, MAP), glycaemic control (fasting insulin, HbA1c, HOMA-B) and insomnia were associated with REI and/or OSA. OSA PRS was associated with BMI, WHR, DBP and glycaemic traits (fasting insulin, HbA1c, HOMA-B and HOMA-IR). MR analysis identified robust causal effects of BMI and WHR on OSA, and probable causal effects of DBP, PP, and HbA1c on OSA/REI. There are shared genetic underpinnings of anthropometric, blood pressure, and glycaemic phenotypes with OSA, with evidence for causal relationships between some phenotypes. Described in Acknowledgments.
Sections du résumé
BACKGROUND
BACKGROUND
Obstructive Sleep Apnoea (OSA) often co-occurs with cardiometabolic and pulmonary diseases. This study is to apply genetic analysis methods to explain the associations between OSA and related phenotypes.
METHODS
METHODS
In the Hispanic Community Healthy Study/Study of Latinos, we estimated genetic correlations ρ
FINDINGS
RESULTS
The dataset included 11,155 participants, 31.03% with OSA. 22 phenotypes were genetically correlated with REI. 10 PRSs covering obesity and fat distribution (BMI, WHR, WHRadjBMI), blood pressure (DBP, PP, MAP), glycaemic control (fasting insulin, HbA1c, HOMA-B) and insomnia were associated with REI and/or OSA. OSA PRS was associated with BMI, WHR, DBP and glycaemic traits (fasting insulin, HbA1c, HOMA-B and HOMA-IR). MR analysis identified robust causal effects of BMI and WHR on OSA, and probable causal effects of DBP, PP, and HbA1c on OSA/REI.
INTERPRETATION
CONCLUSIONS
There are shared genetic underpinnings of anthropometric, blood pressure, and glycaemic phenotypes with OSA, with evidence for causal relationships between some phenotypes.
FUNDING
BACKGROUND
Described in Acknowledgments.
Identifiants
pubmed: 36174398
pii: S2352-3964(22)00470-4
doi: 10.1016/j.ebiom.2022.104288
pmc: PMC9515437
pii:
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104288Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL145425
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153805
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135818
Pays : United States
Organisme : NHLBI NIH HHS
ID : R03 HL154284
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153814
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests Dr. Gottlieb reports receiving fees for clinical consulting from Advance Medical and Teladoc, and membership on the Scientific Advisory Boards of Signifier Medical Technologies and Wesper, Inc. Dr. Redline reports consulting fees from Eli Lilly Inc, Jazz Pharma, and Apnimed Inc, serving as an unpaid board member in the Alliance for Sleep Apnoea Partners, and receipt of loaned oxygen concentrators from Philips Respironics and loaned polysomnography equipment from Nox Medical to a multi-site study. Dr. Zee reports consulting fees from Jazz Pharma, on the topic of treatment of excessive sleepiness in OSA; payment for a CME lecture from WEBMD/Medscape; unpaid membership in the advocacy committee of the Sleep Research Society, serving as an unpaid president of the World Sleep Society, and spousal ownership of stock or stock options of Teva. Dr. Shah reports receiving a grant from NHLBI R01HL143221, and a grant from the AASM Foundation 250-SR-21.