Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells.

Humans Zika Virus Zika Virus Infection Myeloid Cells Stem Cells Interferons
GBM Zika flavivirus glioblastoma interferon macrophage microglia myeloid neural oncolytic

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
07 12 2022
Historique:
received: 04 06 2022
revised: 10 08 2022
accepted: 01 09 2022
pubmed: 30 9 2022
medline: 15 12 2022
entrez: 29 9 2022
Statut: ppublish

Résumé

Zika virus (ZIKV) can infect human developing brain (HDB) progenitors resulting in epidemic microcephaly, whereas analogous cellular tropism offers treatment potential for the adult brain cancer, glioblastoma (GBM). We compared productive ZIKV infection in HDB and GBM primary tissue explants that both contain SOX2+ neural progenitors. Strikingly, although the HDB proved uniformly vulnerable to ZIKV infection, GBM was more refractory, and this correlated with an innate immune expression signature. Indeed, GBM-derived CD11b+ microglia/macrophages were necessary and sufficient to protect progenitors against ZIKV infection in a non-cell autonomous manner. Using SOX2+ GBM cell lines, we found that CD11b+-conditioned medium containing type 1 interferon beta (IFNβ) promoted progenitor resistance to ZIKV, whereas inhibition of JAK1/2 signaling restored productive infection. Additionally, CD11b+ conditioned medium, and IFNβ treatment rendered HDB progenitor lines and explants refractory to ZIKV. These findings provide insight into neuroprotection for HDB progenitors as well as enhanced GBM oncolytic therapies.

Identifiants

DOI: 10.1016/j.neuron.2022.09.002 PMID: 36174572 PMC: PMC7615581
pubmed: 36174572
pii: S0896-6273(22)00807-8
doi: 10.1016/j.neuron.2022.09.002
pmc: PMC7615581
mid: EMS193590
pii:
doi:

Substances chimiques

Interferons 9008-11-1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3936-3951.e10

Subventions

Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 223011
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 28592
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007031
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202471
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 24455
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 108139
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202471/Z/16/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 21992
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Harry Bulstrode (H)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: hb252@cam.ac.uk.

Gemma C Girdler (GC)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Tannia Gracia (T)

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.

Alexander Aivazidis (A)

Wellcome Sanger Institute, Hinxton CB10 1SA, UK.

Ilias Moutsopoulos (I)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.

Adam M H Young (AMH)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

John Hancock (J)

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.

Xiaoling He (X)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.

Katherine Ridley (K)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

Zhaoyang Xu (Z)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

John H Stockley (JH)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

John Finlay (J)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

Clement Hallou (C)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

Teodoro Fajardo (T)

Department of Virology, University of Cambridge, Cambridge CB2 0QQ, UK; Department of Virology, Royal London Hospital, Barts Health NHS Trust, London E1 2ES, UK.

Daniel M Fountain (DM)

Manchester Centre for Clinical Neurosciences, Manchester M6 8HD, UK.

Stijn van Dongen (S)

Wellcome Sanger Institute, Hinxton CB10 1SA, UK.

Alexis Joannides (A)

Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Robert Morris (R)

Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Richard Mair (R)

Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Colin Watts (C)

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2SY, UK.

Thomas Santarius (T)

Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Stephen J Price (SJ)

Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Peter J A Hutchinson (PJA)

Division of Academic Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Emma J Hodson (EJ)

Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB2 0QQ, UK.

Steven M Pollard (SM)

Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.

Irina Mohorianu (I)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.

Roger A Barker (RA)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.

Trevor R Sweeney (TR)

Department of Virology, University of Cambridge, Cambridge CB2 0QQ, UK; The Pirbright Institute, Guildford, Surrey GU24 0NF, UK.

Omer Bayraktar (O)

Wellcome Sanger Institute, Hinxton CB10 1SA, UK.

Fanni Gergely (F)

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address: fanni.gergely@bioch.ox.ac.uk.

David H Rowitch (DH)

Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Wellcome Sanger Institute, Hinxton CB10 1SA, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: dhr25@medschl.cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Myeloid cell interferon secretion restricts...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus Zika › Myeloid cell interferon secretion restricts...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Flaviviridae › Infections à flavivirus › Infection par le virus Zika › Myeloid cell interferon secretion restricts...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Myeloid cell interferon secretion restricts...
questionsmedicales.fr › Cellules › Cellules souches › Myeloid cell interferon secretion restricts...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Myeloid cell interferon secretion restricts...