The presence of sodium glucose co-transporter 2 in mesangial cells and pericytes and its roles in mesangial lesions and in capillaries under diabetic and ischemic conditions.
Hyperglycemia
Ischemia
Mesangial cells
Pericytes
Sodium glucose cotransporter 2
Journal
Diabetes research and clinical practice
ISSN: 1872-8227
Titre abrégé: Diabetes Res Clin Pract
Pays: Ireland
ID NLM: 8508335
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
27
08
2022
accepted:
21
09
2022
pubmed:
30
9
2022
medline:
2
11
2022
entrez:
29
9
2022
Statut:
ppublish
Résumé
SGLT2 is expressed in mesangial cells and pericytes, and is upregulated byhigh glucose and ischemia. Upregulated SGLT2 in both cells might directly worsen ischemia in kidney interstitial legion, heart and brain. The overexpression of SGLT2 in these cells could induce various organ failures via damages or loss of capillaries and dysfunctions of mesangial cells, which are attenuated by SGLT2 inhibitors.
Identifiants
pubmed: 36174778
pii: S0168-8227(22)00910-X
doi: 10.1016/j.diabres.2022.110096
pii:
doi:
Substances chimiques
Sodium-Glucose Transporter 2
0
Glucose
IY9XDZ35W2
Sodium
9NEZ333N27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110096Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.