Nanotechnology for research and treatment of the intestine.


Journal

Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208

Informations de publication

Date de publication:
29 Sep 2022
Historique:
received: 26 04 2022
accepted: 14 06 2022
entrez: 29 9 2022
pubmed: 30 9 2022
medline: 4 10 2022
Statut: epublish

Résumé

The establishment of intestinal in vitro models is crucial for elucidating intestinal cell-microbe intrinsic connections and interaction mechanisms to advance normalized intestinal diagnosis and precision therapy. This review discusses the application of nanomaterials in mucosal therapy and mechanism research in combination with the study of nanoscaffold in vitro models of the gut. By reviewing the original properties of nanomaterials synthesized by different physicochemical principles and modifying the original properties, the contribution of nanomaterials to solving the problems of short survival period, low cell differentiation rate, and poor reduction ability in traditional intestinal models is explored. According to nanomaterials' different diagnostic mediators and therapeutic targets, the current diagnostic principles in inflammatory bowel disease, intestinal cancer, and other diseases are summarized inductively. In addition, the mechanism of action of nanomedicines in repairing mucosa, inhibiting inflammation, and alleviating the disease process is also discussed. Through such systematic elaboration, it offers a basis for nanomaterials to help advance in vitro research on the intestine and provide precision treatments in the clinic.

Identifiants

pubmed: 36175955
doi: 10.1186/s12951-022-01517-3
pii: 10.1186/s12951-022-01517-3
pmc: PMC9523975
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

430

Subventions

Organisme : National Natural Science Foundation of China
ID : 22004035
Organisme : China Postdoctoral Science Foundation
ID : 2020TQ0094
Organisme : The Science and Technology Innovation Program of Hunan Province
ID : 2020RC2054
Organisme : Hunan Provincial Science and Technology Department
ID : 2021JJ40230
Organisme : Hunan Provincial Science and Technology Department
ID : 2020NK2004
Organisme : Double first-class construction project of Hunan Agricultural University
ID : SYL201802003

Informations de copyright

© 2022. The Author(s).

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Auteurs

Yanquan Fei (Y)

College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, 410128, Hunan, China.

Yong Ma (Y)

College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, 410128, Hunan, China.

Huaizu Zhang (H)

College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, 410128, Hunan, China.

Hao Li (H)

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China.

Guangfu Feng (G)

College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, 410128, Hunan, China. GuangfuFeng@hunau.edu.cn.

Jun Fang (J)

College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, 410128, Hunan, China. fangjun1973@hunau.edu.cn.

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