Reinfection and reactivation of SARS-CoV-2.
COVID-19
SARS-CoV-2
reactivation
reinfection
Journal
Future virology
ISSN: 1746-0794
Titre abrégé: Future Virol
Pays: England
ID NLM: 101278124
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
08
08
2021
accepted:
31
08
2022
entrez:
30
9
2022
pubmed:
1
10
2022
medline:
1
10
2022
Statut:
ppublish
Résumé
As the cases of SARS-CoV-2 infection escalates, the essence of in-depth knowledge around acquired immunity and emergence of reinfection and reactivation have to be captured. While being a rare phenomenon, reinfection occurs as the result of diminishing protection conferred by antibodies, especially IgG. Reactivation is more concerned with the role of various elements including shedding lingering viral RNA for a prolonged time and incomplete resolution of infection along with the insight of dormant viral exosomes' role. The concept of testing positive after two consecutive negative results requires proper discrimination of reinfection from reactivation. In this review, we summarized the current evidence for possible mechanisms leading to viral reactivation or test re-positivity. We also pointed out risk factors associated with both reinfection and reactivation.
Identifiants
pubmed: 36176508
doi: 10.2217/fvl-2021-0212
pmc: PMC9514089
doi:
Types de publication
Journal Article
Review
Langues
eng
Informations de copyright
© 2022 Future Medicine Ltd.
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