Liquid biopsies in primary and secondary bone cancers.
Ewing sarcoma
Liquid biopsy
bone metastasis
drug resistance
extracellular vesicles
minimal residual disease
osteosarcoma
Journal
Cancer drug resistance (Alhambra, Calif.)
ISSN: 2578-532X
Titre abrégé: Cancer Drug Resist
Pays: United States
ID NLM: 101738710
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
02
2022
revised:
22
04
2022
accepted:
25
05
2022
entrez:
30
9
2022
pubmed:
1
10
2022
medline:
1
10
2022
Statut:
epublish
Résumé
Liquid biopsies are a powerful tool to non-invasively analyze tumor phenotype and progression as well as drug resistance. In the bone oncology field, liquid biopsies would be particularly important to develop, since standard biopsies can be very painful, dangerous (e.g., when found in proximity to the spinal cord), and hard to collect. In this review, we explore the recent advances in liquid biopsies in both primary (osteosarcoma and Ewing sarcoma) and secondary bone cancers (breast, prostate, and lung cancer-induced bone metastases), presenting their current role and highlighting their unexpressed potential, as well as the barriers limiting their possible adoption, including costs, scalability, reproducibility, and isolation methods. We discuss the use of circulating tumor cells, cell-free circulating tumor DNA, and extracellular vesicles for the purpose of improving diagnosis, prognosis, evaluation of therapy resistance, and driving therapy decisions in both primary and secondary bone malignancies.
Identifiants
pubmed: 36176757
doi: 10.20517/cdr.2022.17
pmc: PMC9511800
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
541-559Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
All authors declared that there are no conflicts of interest.
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