Microarray meta-analysis reveals IL6 and p38β/MAPK11 as potential targets of hsa-miR-124 in endothelial progenitor cells: Implications for stent re-endothelization in diabetic patients.

circulating progenitor endothelial cells diabetes micro-RNA microarray meta-analysis stent restenosis

Journal

Frontiers in cardiovascular medicine

ISSN: 2297-055X

Titre abrégé: Front Cardiovasc Med

Pays: Switzerland

ID NLM: 101653388

Informations de publication

Date de publication:
2022

Historique:

received: 08 06 2022

accepted: 25 08 2022

entrez: 30 9 2022

pubmed: 1 10 2022

medline: 1 10 2022

Statut: epublish

Résumé

Circulating endothelial progenitor cells (EPCs) play an important role in the repair processes of damaged vessels, favoring re-endothelization of stented vessels to minimize restenosis. EPCs number and function is diminished in patients with type 2 diabetes, a known risk factor for restenosis. Considering the impact of EPCs in vascular injury repair, we conducted a meta-analysis of microarray to assess the transcriptomic profile and determine target genes during the differentiation process of EPCs into mature ECs. Five microarray datasets, including 13 EPC and 12 EC samples were analyzed, using the online tool ExpressAnalyst. Differentially expressed genes (DEGs) analysis was done by Limma method, with an | log

Identifiants

DOI: 10.3389/fcvm.2022.964721 PMID: 36176980 PMC: PMC9513120

pubmed: 36176980

doi: 10.3389/fcvm.2022.964721

pmc: PMC9513120

doi:

Types de publication

Journal Article

Langues

eng

Pagination

964721

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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