Cross-sectional study of primary antimicrobial treatment and vaccination coverage in outbreaks of bovine respiratory disease on dairy and beef farms in northern Belgium.
antimicrobial resistance
antimicrobial stewardship
cattle
non-steroidal anti-inflammatory drugs
pneumonia
Journal
The Veterinary record
ISSN: 2042-7670
Titre abrégé: Vet Rec
Pays: England
ID NLM: 0031164
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
22
08
2022
received:
31
05
2022
accepted:
07
09
2022
pubmed:
1
10
2022
medline:
6
12
2022
entrez:
30
9
2022
Statut:
ppublish
Résumé
To what extent veterinarians active in the dairy or beef sector follow the antimicrobial therapy guidelines made available in different European countries for bovine respiratory disease (BRD) outbreaks, and whether differences in therapeutic or preventive preferences for BRD management exist, is currently unknown. Therefore, the objectives of this cross-sectional study were to compare vaccination coverage and primary antimicrobial and anti-inflammatory treatment on dairy, beef and mixed-breed farms in northern Belgium, and determine their compliance with the recommendations made by the Belgian formulary. Information on antimicrobial and anti-inflammatory drug use and vaccination coverage from 190 BRD outbreaks in 180 herds, submitted by 101 veterinarians, was analysed. Multivariable linear probability models, adjusted for clustering at the veterinarian level, were used to determine differences between dairy and beef farms. Antimicrobials and non-steroidal anti-inflammatory drugs (NSAIDs) were used in 93.5% and 81.7% of the BRD outbreaks, respectively. First-line antimicrobials were used as primary treatment in only 42.3%, 50.9% and 38.6% of dairy, beef and mixed-breed farms, respectively. Significant differences (p < 0.05) were observed between dairy and beef farms in terms of use of long-acting macrolides (-17.2 percentage points [pp]; 95% confidence interval [CI]: -31.9, -2.5), steroidal anti-inflammatory drugs (15.2 pp; CI: 0.5, 29.8) and vaccination coverage (bovine respiratory syncytial virus, parainfluenza virus type 3 [33.1 pp; Cl: 15.7-50.6] and Mannheimia haemolytica [23.1 pp; Cl: 3.4-39.8]). The herds that participated in this study were likely among the more motivated regarding BRD control. As such, the information on vaccination coverage is likely not entirely representative of herds in the study area. Interpretation is further complicated by the fact that vaccinated herds were potentially less likely to face a BRD outbreak and therefore participate in the current study. This study reveals differences in the primary use of (N)SAIDs, type of antimicrobials used and vaccination coverage on beef and dairy farms in the study region, and also differences in the appropriateness of antimicrobial selection based on the Belgian formulary.
Sections du résumé
BACKGROUND
To what extent veterinarians active in the dairy or beef sector follow the antimicrobial therapy guidelines made available in different European countries for bovine respiratory disease (BRD) outbreaks, and whether differences in therapeutic or preventive preferences for BRD management exist, is currently unknown. Therefore, the objectives of this cross-sectional study were to compare vaccination coverage and primary antimicrobial and anti-inflammatory treatment on dairy, beef and mixed-breed farms in northern Belgium, and determine their compliance with the recommendations made by the Belgian formulary.
METHODS
Information on antimicrobial and anti-inflammatory drug use and vaccination coverage from 190 BRD outbreaks in 180 herds, submitted by 101 veterinarians, was analysed. Multivariable linear probability models, adjusted for clustering at the veterinarian level, were used to determine differences between dairy and beef farms.
RESULTS
Antimicrobials and non-steroidal anti-inflammatory drugs (NSAIDs) were used in 93.5% and 81.7% of the BRD outbreaks, respectively. First-line antimicrobials were used as primary treatment in only 42.3%, 50.9% and 38.6% of dairy, beef and mixed-breed farms, respectively. Significant differences (p < 0.05) were observed between dairy and beef farms in terms of use of long-acting macrolides (-17.2 percentage points [pp]; 95% confidence interval [CI]: -31.9, -2.5), steroidal anti-inflammatory drugs (15.2 pp; CI: 0.5, 29.8) and vaccination coverage (bovine respiratory syncytial virus, parainfluenza virus type 3 [33.1 pp; Cl: 15.7-50.6] and Mannheimia haemolytica [23.1 pp; Cl: 3.4-39.8]).
LIMITATIONS
The herds that participated in this study were likely among the more motivated regarding BRD control. As such, the information on vaccination coverage is likely not entirely representative of herds in the study area. Interpretation is further complicated by the fact that vaccinated herds were potentially less likely to face a BRD outbreak and therefore participate in the current study.
CONCLUSION
This study reveals differences in the primary use of (N)SAIDs, type of antimicrobials used and vaccination coverage on beef and dairy farms in the study region, and also differences in the appropriateness of antimicrobial selection based on the Belgian formulary.
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2235Informations de copyright
© 2022 British Veterinary Association.
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