Hypogammaglobulinemia in pediatric kidney transplant recipients.
Immunoglobulin
Infection
Kidney
Pediatric transplant
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
18
05
2022
accepted:
12
09
2022
revised:
27
08
2022
medline:
4
5
2023
pubmed:
1
10
2022
entrez:
30
9
2022
Statut:
ppublish
Résumé
Infections remain the most common cause of hospitalization after kidney transplantation, contributing to significant post-transplant morbidity and mortality. There is a growing body of literature that suggests that immunoglobulins may have a significant protective role against post-transplant infections, although the literature remains sparse, inconsistent, and not well publicized among pediatric nephrologists. Of great concern are data indicating a high prevalence of immunoglobulin abnormalities following transplantation and a possible link between these abnormalities and poorer outcomes. Our educational review focuses on the epidemiology and risk factors for the development of immunoglobulin abnormalities after kidney transplantation, the outcomes in patients with low immunoglobulin levels, and studies evaluating possible interventions to correct these immunoglobulin abnormalities.
Identifiants
pubmed: 36178549
doi: 10.1007/s00467-022-05757-1
pii: 10.1007/s00467-022-05757-1
pmc: PMC10154257
doi:
Substances chimiques
Immunoglobulins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1753-1762Informations de copyright
© 2022. The Author(s).
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