Functional neural changes associated with psychotherapy in anxiety disorders - A meta-analysis of longitudinal fMRI studies.


Journal

Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090

Informations de publication

Date de publication:
11 2022
Historique:
received: 15 04 2022
revised: 12 08 2022
accepted: 25 09 2022
pubmed: 1 10 2022
medline: 9 11 2022
entrez: 30 9 2022
Statut: ppublish

Résumé

Successful psychotherapy for anxiety disorders is thought to be linked to functional neural changes in prefrontal control areas and fear-related limbic regions. Thus, discovering such therapy-associated neural changes might point to relevant mechanisms of action. Using AES-SDM, we conducted a coordinate-based meta-analysis of 22 whole-brain datasets (n = 419 anxiety patients) from 18 studies identified by our systematic literature search following PRISMA criteria (preregistration available at OSF: https://osf.io/dgc4p). In these studies, fMRI data was collected in response to negative stimuli during cognitive-emotional tasks before and after psychotherapy. Post-psychotherapy, activation decreased in the right insula, the anterior cingulate cortex, and the dorsolateral prefrontal cortex; no region had increased activation. A subgroup analysis for CBT revealed additional decrease in the supplementary motor area. Reduced activation in limbic and frontal regions might indicate therapy-associated normalization regarding the perception of internal and external threat, subsequent allocation of cognitive resources, and changes in cognitive control. Due to the integration of diverse treatments and experimental tasks, these changes presumably reflect global effects of successful psychotherapy.

Identifiants

pubmed: 36179918
pii: S0149-7634(22)00384-0
doi: 10.1016/j.neubiorev.2022.104895
pii:
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Review Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

104895

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Elisabeth Schrammen (E)

Institute for Translational Psychiatry, University of Münster, Germany. Electronic address: e.schrammen@uni-muenster.de.

Kati Roesmann (K)

Institute for Clinical Psychology and Psychotherapy, University of Siegen, Germany.

David Rosenbaum (D)

Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Germany.

Ronny Redlich (R)

Institute of Psychology, University of Halle, Germany.

Jana Harenbrock (J)

Institute for Translational Psychiatry, University of Münster, Germany.

Udo Dannlowski (U)

Institute for Translational Psychiatry, University of Münster, Germany.

Elisabeth J Leehr (EJ)

Institute for Translational Psychiatry, University of Münster, Germany.

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Classifications MeSH