Measuring Binding at the Putative Melatonin Receptor MT3.

5-Methoxytryptamine Animals Antioxidants Binding Sites Ligands Mammals / metabolism Melatonin / metabolism Quinone Reductases / metabolism Receptors, Melatonin / metabolism
2-iodoMCA-NAT Binding Brain Fast kinetics Melatonin NQO2

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2022
Historique:
entrez: 30 9 2022
pubmed: 1 10 2022
medline: 5 10 2022
Statut: ppublish

Résumé

Melatonin, (N-acetyl-5-methoxytryptamine), is a neurohormone which possesses a wide range of biological effects. The effects mediated by melatonin are in part attributed to the antioxidant properties of the molecule. For a long time, melatonin had been described as a ligand of a putative "receptor" present in mammalian brains named MT

Identifiants

DOI: 10.1007/978-1-0716-2593-4_30 PMID: 36180699
pubmed: 36180699
doi: 10.1007/978-1-0716-2593-4_30
doi:

Substances chimiques

Antioxidants 0
Ligands 0
Receptors, Melatonin 0
5-Methoxytryptamine 3VMW6141KC
Quinone Reductases EC 1.6.99.-
Melatonin JL5DK93RCL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

283-289

Informations de copyright

© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Références

Reppert SM, Weaver DR, Ebisawa T (1994) Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 13:1177–1185. https://doi.org/10.1016/0896-6273(94)90055-8
doi: 10.1016/0896-6273(94)90055-8 pubmed: 7946354
Reppert SM, Weaver DR, Cassone VM et al (1995) Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain. Neuron 15:1003–1015. https://doi.org/10.1016/0896-6273(95)90090-X
doi: 10.1016/0896-6273(95)90090-X pubmed: 7576645
Reppert SM, Godson C, Mahle CD et al (1995) Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci U S A 92:8734–8738. https://doi.org/10.1073/pnas.92.19.8734
doi: 10.1073/pnas.92.19.8734 pubmed: 7568007 pmcid: 41041
Villas-Boas GR, Lavorato SN, Paes MM et al (2021) Modulation of the serotonergic receptosome in the treatment of anxiety and depression: a narrative review of the experimental evidence. Pharmaceuticals (Basel) 14:148. https://doi.org/10.3390/ph14020148
doi: 10.3390/ph14020148
Reppert SM, Weaver DR, Ebisawa T et al (1996) Cloning of a melatonin-related receptor from human pituitary. FEBS Lett 386:219–224. https://doi.org/10.1016/0014-5793(96)00437-1
doi: 10.1016/0014-5793(96)00437-1 pubmed: 8647286
Dufourny L, Levasseur A, Migaud M et al (2008) GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals. BMC Evol Biol 8:105. https://doi.org/10.1186/1471-2148-8-105
doi: 10.1186/1471-2148-8-105 pubmed: 18400093 pmcid: 2323367
Gautier C, Guenin S-P, Riest-Fery I et al (2018) Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). PLoS One 13:e0191904. https://doi.org/10.1371/journal.pone.0191904
doi: 10.1371/journal.pone.0191904 pubmed: 29529033 pmcid: 5846726
Shabajee-Alibay P, Bonnaud A, Malpaux B et al (2021) A putative new melatonin binding site in sheep brain, MTx: preliminary observations and characteristics. J Pharmacol Exp Ther 27:JPET-AR-2021-000785. https://doi.org/10.1124/jpet.121.000785
doi: 10.1124/jpet.121.000785
Duncan MJ, Takahashi JS, Dubocovich ML (1988) 2-125Iiodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 122:1825–1833. https://doi.org/10.1210/endo-122-5-1825
doi: 10.1210/endo-122-5-1825 pubmed: 2834175
Duncan MJ, Takahashi JS, Dubocovich ML (1989) Characteristics and autoradiographic localization of 2-125Iiodomelatonin binding sites in Djungarian hamster brain. Endocrinology 125:1011–1018. https://doi.org/10.1210/endo-125-2-1011
doi: 10.1210/endo-125-2-1011 pubmed: 2752961
Paul P, Lahaye C, Delagrange P et al (1999) Characterization of 2-125Iiodomelatonin binding sites in Syrian hamster peripheral organs. J Pharmacol Exp Ther 290:334–340
pubmed: 10381796
Nosjean O, Nicolas J-P, Klupsch F et al (2001) Comparative pharmacological studies of melatonin receptors: mt1, mt2 and mt3/qr2. tissue distribution of mt3/qr2. Biochem Pharmacol 61:1369–1379. https://doi.org/10.1016/s0006-2952(01)00615-3
Nosjean O, Ferro M, Coge F et al (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275:31311–31317. https://doi.org/10.1074/jbc.M005141200
doi: 10.1074/jbc.M005141200 pubmed: 10913150
Boutin JA, Ferry G (2019) Is there sufficient evidence that the melatonin binding site MT3 is quinone reductase 2? J Pharmacol Exp Ther 368:59–65. https://doi.org/10.1124/jpet.118.253260
doi: 10.1124/jpet.118.253260 pubmed: 30389722
Cecon E, Legros C, Boutin JA et al (2021) Journal of pineal research guideline for authors: defining and characterizing melatonin targets. J Pineal Res 70:e12712. https://doi.org/10.1111/jpi.12712
doi: 10.1111/jpi.12712 pubmed: 33332653
Molinari EJ, North PC, Dubocovich ML (1996) 2-[125I]Iodo-5-methoxycarbonylamino-N-acetyltryptamine: a selective radioligand for the characterization of melatonin ML2 binding sites. Eur J Pharmacol 301:159–168. https://doi.org/10.1016/0014-2999(95)00870-5
doi: 10.1016/0014-2999(95)00870-5 pubmed: 8773460
Vincent L, Cohen W, Delagrange P et al (2010) Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand. J Pineal Res 48:222–229. https://doi.org/10.1111/j.1600-079X.2010.00746.x
doi: 10.1111/j.1600-079X.2010.00746.x pubmed: 20210850
Mailliet F, Ferry G, Vella F et al (2005) Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme. Biochem Pharmacol 71:74–88. https://doi.org/10.1016/j.bcp.2005.09.030
doi: 10.1016/j.bcp.2005.09.030 pubmed: 16293234
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. https://doi.org/10.1006/abio.1976.9999
doi: 10.1006/abio.1976.9999 pubmed: 942051
Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann N Y Acad Sci 51:660–672. https://doi.org/10.1111/j.1749-6632.1949.tb27297.x
doi: 10.1111/j.1749-6632.1949.tb27297.x
Cheng Y-C, Prusoff WH (1973) Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22:3099–3108. https://doi.org/10.1016/0006-2952(73)90196-2
doi: 10.1016/0006-2952(73)90196-2 pubmed: 4202581
Calamini B, Santarsiero BD, Boutin JA et al (2008) Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J 413:81–91. https://doi.org/10.1042/BJ20071373
doi: 10.1042/BJ20071373 pubmed: 18254726

Auteurs

Céline Legros (C)

Eurofins, Discovery, Eurofins Cerep, Celle-Levescault, France.

Philippe Dupuis (P)

Eurofins, Discovery, Eurofins Cerep, Celle-Levescault, France.

Gilles Ferry (G)

Pole d'expertise Biotechnologie, Chimie & Biologie, Institut de Recherches Servier, Croissy-sur-Seine, France.

Jean A Boutin (JA)

Pole d'expertise Biotechnologie, Chimie & Biologie, Institut de Recherches Servier, Croissy-sur-Seine, France. ja.boutin.pro@gmail.com.
Pharma-Dev, UMR 152, Université de Toulouse, Toulouse, France. ja.boutin.pro@gmail.com.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Tryptamines › 5-Méthoxy-tryptamine › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Eucaryotes › Animaux › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Mélatonine › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › NADH, NADPH oxidoreductases › Quinone reductases › Measuring Binding at the Putative Melatonin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs à la mélatonine › Measuring Binding at the Putative Melatonin...