Stroke genetics informs drug discovery and risk prediction across ancestries.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
15
12
2021
accepted:
29
07
2022
pubmed:
1
10
2022
medline:
5
11
2022
entrez:
30
9
2022
Statut:
ppublish
Résumé
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry
Identifiants
pubmed: 36180795
doi: 10.1038/s41586-022-05165-3
pii: 10.1038/s41586-022-05165-3
pmc: PMC9524349
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115-123Subventions
Organisme : BLRD VA
ID : I01 BX004821
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS041588
Pays : United States
Organisme : British Heart Foundation
ID : RG/13/13/30194
Pays : United Kingdom
Organisme : NLM NIH HHS
ID : R01 LM010685
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : Medical Research Council
ID : MC_U137686851
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS114045
Pays : United States
Organisme : British Heart Foundation
ID : CH/1996001/9454
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K08 HL153950
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_13049
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U137686854
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/13/33946
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG072975
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_12028
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0300622
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 212946/Z/18/Z
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK084350
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_12027
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12026/2
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00017/1
Pays : United Kingdom
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_12029
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14135
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_G0801669
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/12/2/29428
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/14/55/30806
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States
Investigateurs
Joshua C Bis
(JC)
Jin-Moo Lee
(JM)
Yu-Ching Cheng
(YC)
James F Meschia
(JF)
Wei Min Chen
(WM)
Michèle M Sale
(MM)
Alan B Zonderman
(AB)
Michele K Evans
(MK)
James G Wilson
(JG)
Adolfo Correa
(A)
Matthew Traylor
(M)
Cathryn M Lewis
(CM)
Cara L Carty
(CL)
Alexander Reiner
(A)
Jeffrey Haessler
(J)
Carl D Langefeld
(CD)
Rebecca F Gottesman
(RF)
Kristine Yaffe
(K)
Yong Mei Liu
(YM)
Charles Kooperberg
(C)
Leslie A Lange
(LA)
Karen L Furie
(KL)
Donna K Arnett
(DK)
Oscar R Benavente
(OR)
Raji P Grewal
(RP)
Leema Reddy Peddareddygari
(LR)
Charles Kooperberg
(C)
Kristian Hveem
(K)
Sara Lindstrom
(S)
Lu Wang
(L)
Erin N Smith
(EN)
William Gordon
(W)
Astrid van Hylckama Vlieg
(A)
Mariza de Andrade
(M)
Jennifer A Brody
(JA)
Jack W Pattee
(JW)
Jeffrey Haessler
(J)
Ben M Brumpton
(BM)
Pierre Suchon
(P)
Ming-Huei Chen
(MH)
Kelly A Frazer
(KA)
Constance Turman
(C)
Marine Germain
(M)
James MacDonald
(J)
Sigrid K Braekkan
(SK)
Sebastian M Armasu
(SM)
Nathan Pankratz
(N)
Rebecca D Jackson
(RD)
Jonas B Nielsen
(JB)
Franco Giulianini
(F)
Marja K Puurunen
(MK)
Manal Ibrahim
(M)
Susan R Heckbert
(SR)
Theo K Bammler
(TK)
Bryan M McCauley
(BM)
Kent D Taylor
(KD)
James S Pankow
(JS)
Alexander P Reiner
(AP)
Maiken E Gabrielsen
(ME)
Jean-François Deleuze
(JF)
Chris J O'Donnell
(CJ)
Jihye Kim
(J)
Barbara McKnight
(B)
Peter Kraft
(P)
John-Bjarne Hansen
(JB)
Frits R Rosendaal
(FR)
John A Heit
(JA)
Weihong Tang
(W)
Pierre-Emmanuel Morange
(PE)
Andrew D Johnson
(AD)
Christopher Kabrhel
(C)
Ewoud J van Dijk
(EJ)
Peter J Koudstaal
(PJ)
Gert-Jan Luijckx
(GJ)
Paul J Nederkoorn
(PJ)
Robert J van Oostenbrugge
(RJ)
Marieke C Visser
(MC)
Marieke J H Wermer
(MJH)
L Jaap Kappelle
(LJ)
Tõnu Esko
(T)
Andres Metspalu
(A)
Reedik Mägi
(R)
Mari Nelis
(M)
Marguerite R Irvin
(MR)
Frank-Erik de Leeuw
(FE)
Christopher R Levi
(CR)
Jane Maguire
(J)
Jordi Jiménez-Conde
(J)
Pankaj Sharma
(P)
Cathie L M Sudlow
(CLM)
Kristiina Rannikmäe
(K)
Reinhold Schmidt
(R)
Agnieszka Slowik
(A)
Joanna Pera
(J)
Vincent N S Thijs
(VNS)
Arne G Lindgren
(AG)
Andreea Ilinca
(A)
Olle Melander
(O)
Gunnar Engström
(G)
Kathryn M Rexrode
(KM)
Peter M Rothwell
(PM)
Tara M Stanne
(TM)
Julie A Johnson
(JA)
John Danesh
(J)
Adam S Butterworth
(AS)
Laura Heitsch
(L)
Giorgio B Boncoraglio
(GB)
Michiaki Kubo
(M)
Alessandro Pezzini
(A)
Arndt Rolfs
(A)
Anne-Katrin Giese
(AK)
David Weir
(D)
Rebecca D Jackson
(RD)
Owen A Ross
(OA)
Robin Lemmons
(R)
Martin Soderholm
(M)
Mary Cushman
(M)
Katarina Jood
(K)
Caitrin W McDonough
(CW)
Steven Bell
(S)
Birgit Linkohr
(B)
Tsong-Hai Lee
(TH)
Jukka Putaala
(J)
Christopher D Anderson
(CD)
Oscar L Lopez
(OL)
Xueqiu Jian
(X)
Ulf Schminke
(U)
Natalia Cullell
(N)
Pilar Delgado
(P)
Laura Ibañez
(L)
Jerzy Krupinski
(J)
Vasileios Lioutas
(V)
Koichi Matsuda
(K)
Joan Montaner
(J)
Elena Muiño
(E)
Jaume Roquer
(J)
Chloe Sarnowski
(C)
Naveed Sattar
(N)
Gerli Sibolt
(G)
Alexander Teumer
(A)
Loes Rutten-Jacobs
(L)
Masahiro Kanai
(M)
Anne-Katrin Giese
(AK)
Solveig Gretarsdottir
(S)
Natalia S Rost
(NS)
Salim Yusuf
(S)
Peter Almgren
(P)
Hakan Ay
(H)
Steve Bevan
(S)
Robert D Brown
(RD)
Caty Carrera
(C)
Julie E Buring
(JE)
Wei-Min Chen
(WM)
Ioana Cotlarciuc
(I)
Paul I W de Bakker
(PIW)
Anita L DeStefano
(AL)
Marcel den Hoed
(M)
Qing Duan
(Q)
Stefan T Engelter
(ST)
Guido J Falcone
(GJ)
Rebecca F Gottesman
(RF)
Stefan Gustafsson
(S)
Ahamad Hassan
(A)
Elizabeth G Holliday
(EG)
George Howard
(G)
Fang-Chi Hsu
(FC)
Erik Ingelsson
(E)
Tamara B Harris
(TB)
Brett M Kissela
(BM)
Dawn O Kleindorfer
(DO)
Claudia Langenberg
(C)
Robin Lemmens
(R)
Didier Leys
(D)
Wei-Yu Lin
(WY)
Erik Lorentzen
(E)
Patrik K Magnusson
(PK)
Patrick F McArdle
(PF)
Sara L Pulit
(SL)
Kenneth Rice
(K)
Saori Sakaue
(S)
Bishwa R Sapkota
(BR)
Christian Tanislav
(C)
Gudmar Thorleifsson
(G)
Unnur Thorsteinsdottir
(U)
Christophe Tzourio
(C)
Cornelia M van Duijn
(CM)
Matthew Walters
(M)
Nicholas J Wareham
(NJ)
Najaf Amin
(N)
Hugo J Aparicio
(HJ)
John Attia
(J)
Alexa S Beiser
(AS)
Claudine Berr
(C)
Mariana Bustamante
(M)
Valeria Caso
(V)
Seung Hoan Choi
(SH)
Ayesha Chowhan
(A)
Jean-François Dartigues
(JF)
Hossein Delavaran
(H)
Marcus Dörr
(M)
Ian Ford
(I)
Wander S Gurpreet
(WS)
Anders Hamsten
(A)
Atsushi Hozawa
(A)
Martin Ingelsson
(M)
Motoki Iwasaki
(M)
Sara Kaffashian
(S)
Lalit Kalra
(L)
Olafur Kjartansson
(O)
Manja Kloss
(M)
Daniel L Labovitz
(DL)
Cathy C Laurie
(CC)
Linxin Li
(L)
Lars Lind
(L)
Cecilia M Lindgren
(CM)
Hirata Makoto
(H)
Naoko Minegishi
(N)
Andrew P Morris
(AP)
Martina Müller-Nurasyid
(M)
Bo Norrving
(B)
Soichi Ogishima
(S)
Eugenio A Parati
(EA)
Nancy L Pedersen
(NL)
Markus Perola
(M)
Pekka Jousilahti
(P)
Silvana Pileggi
(S)
Raquel Rabionet
(R)
Iolanda Riba-Llena
(I)
Marta Ribasés
(M)
Jose R Romero
(JR)
Anthony G Rudd
(AG)
Antti-Pekka Sarin
(AP)
Ralhan Sarju
(R)
Mamoru Satoh
(M)
Norie Sawada
(N)
Ásgeir Sigurdsson
(Á)
Albert Smith
(A)
O Colin Stine
(OC)
David J Stott
(DJ)
Konstantin Strauch
(K)
Takako Takai
(T)
Hideo Tanaka
(H)
Emmanuel Touze
(E)
Shoichiro Tsugane
(S)
Andre G Uitterlinden
(AG)
Einar M Valdimarsson
(EM)
Sven J van der Lee
(SJ)
Kenji Wakai
(K)
Stephen R Williams
(SR)
Charles D A Wolfe
(CDA)
Quenna Wong
(Q)
Taiki Yamaji
(T)
Dharambir K Sanghera
(DK)
Kari Stefansson
(K)
Kent D Taylor
(KD)
Nicolas Martinez-Majander
(N)
Kenji Sobue
(K)
Carolina Soriano-Tárraga
(C)
Henry Völzke
(H)
Onoja Akpa
(O)
Fred S Sarfo
(FS)
Albert Akpalu
(A)
Reginald Obiako
(R)
Kolawole Wahab
(K)
Godwin Osaigbovo
(G)
Lukman Owolabi
(L)
Morenikeji Komolafe
(M)
Carolyn Jenkins
(C)
Oyedunni Arulogun
(O)
Godwin Ogbole
(G)
Abiodun M Adeoye
(AM)
Joshua Akinyemi
(J)
Atinuke Agunloye
(A)
Adekunle G Fakunle
(AG)
Ezinne Uvere
(E)
Abimbola Olalere
(A)
Olayinka J Adebajo
(OJ)
Junshi Chen
(J)
Robert Clarke
(R)
Rory Collins
(R)
Yu Guo
(Y)
Chen Wang
(C)
Jun Lv
(J)
Richard Peto
(R)
Yiping Chen
(Y)
Zammy Fairhurst-Hunter
(Z)
Michael Hill
(M)
Alfred Pozarickij
(A)
Dan Schmidt
(D)
Becky Stevens
(B)
Iain Turnbull
(I)
Canqing Yu
(C)
Quentin Le Grand
(Q)
Leslie E Ferreira
(LE)
Akiko Nagai
(A)
Yoishinori Murakami
(Y)
Mirjam I Geerlings
(MI)
Natalie C Gasca
(NC)
Vilmundur Gudnason
(V)
Marion van Vugt
(M)
Rebecca F Gottesman
(RF)
Eric J Shiroma
(EJ)
Sigurdur Sigurdsson
(S)
Mohsen Ghanbari
(M)
Eric Boerwinkle
(E)
Alexa S Beiser
(AS)
Bernard Fongang
(B)
Ruiqi Wang
(R)
Mohammad K Ikram
(MK)
Uwe Völker
(U)
Phil L de Jager
(PL)
Rafael de Cid
(R)
Børge G Nordestgaard
(BG)
Muralidharan Sargurupremraj
(M)
Shefali S Verma
(SS)
Karlijn F de Laat
(KF)
Anouk G W van Norden
(AGW)
Paul L de Kort
(PL)
Sarah E Vermeer
(SE)
Paul J A M Brouwers
(PJAM)
Rob A R Gons
(RAR)
Paul J Nederkoorn
(PJ)
Tom den Heijer
(T)
Gert W van Dijk
(GW)
Frank G W van Rooij
(FGW)
Anne H Aamodt
(AH)
Anne H Skogholt
(AH)
Ben M Brumpton
(BM)
Cristen J Willer
(CJ)
Ingrid Heuch
(I)
Knut Hagen
(K)
Lars G Fritsche
(LG)
Linda M Pedersen
(LM)
Maiken E Gabrielsen
(ME)
Hanne Ellekjær
(H)
Wei Zhou
(W)
Amy E Martinsen
(AE)
Espen S Kristoffersen
(ES)
Jonas B Nielsen
(JB)
Kristian Hveem
(K)
Laurent F Thomas
(LF)
Christoph Kleinschnitz
(C)
Stefan Frantz
(S)
Kathrin Ungethüm
(K)
Cristina Gallego-Fabrega
(C)
Miquel Lledós
(M)
Laia Llucià-Carol
(L)
Tomas Sobrino
(T)
Francisco Campos
(F)
José Castillo
(J)
Marimar Freijó
(M)
Juan Francisco Arenillas
(JF)
Victor Obach
(V)
José Álvarez-Sabín
(J)
Carlos A Molina
(CA)
Marc Ribó
(M)
Lucia Muñoz-Narbona
(L)
Elena Lopez-Cancio
(E)
Mònica Millán
(M)
Rosa Diaz-Navarro
(R)
Cristòfol Vives-Bauza
(C)
Gemma Serrano-Heras
(G)
Tomás Segura
(T)
Pilar Delgado
(P)
Rajat Dhar
(R)
Raquel Delgado-Mederos
(R)
Luis Prats-Sánchez
(L)
Pol Camps-Renom
(P)
Natalia Blay
(N)
Lauro Sumoy
(L)
Joan Martí-Fàbregas
(J)
Peter Schnohr
(P)
Gorm B Jensen
(GB)
Marianne Benn
(M)
Shoaib Afzal
(S)
Pia R Kamstrup
(PR)
Jessica van Setten
(J)
Sander W van der Laan
(SW)
Jet M J Vonk
(JMJ)
Bong-Jo Kim
(BJ)
Sami Curtze
(S)
Marjaana Tiainen
(M)
Janne Kinnunen
(J)
Vilas Menon
(V)
Yun Ju Sung
(YJ)
Chengran Yang
(C)
Florence Saillour-Glenisson
(F)
Simon Gravel
(S)
N Charlotte Onland-Moret
(NC)
Alicia K Heath
(AK)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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