NPWT resource use compared with standard moist wound care in diabetic foot wounds: DiaFu randomized clinical trial results.
Diabetic foot
Negative pressure wound therapy
Resource use
Wound
Wound care
Journal
Journal of foot and ankle research
ISSN: 1757-1146
Titre abrégé: J Foot Ankle Res
Pays: England
ID NLM: 101471610
Informations de publication
Date de publication:
30 Sep 2022
30 Sep 2022
Historique:
received:
20
12
2021
accepted:
24
08
2022
entrez:
30
9
2022
pubmed:
1
10
2022
medline:
5
10
2022
Statut:
epublish
Résumé
Diabetic foot ulcers not only have a negative impact on patient mortality, morbidity and quality of life, but also require high resource utilization to achieve complete wound healing. The aim of this evaluation was to compare resource utilization of negative pressure wound therapy (NPWT) and standard moist wound care (SMWC) for diabetic foot wounds after amputation, surgical debridement or wound cleansing. The multicenter clinical DiaFu study enrolled 368 adults with diabetic foot ulcers between December 23, 2011 and October 21, 2014. Patients were randomly assigned to NPWT and SMWC. Evaluation of direct resource use comprised inpatient and outpatient treatment time, and personnel and material for wound treatment within 16 weeks. This resource use analysis was primarily based on the per protocol population (NPWT 44; SMWC 110). Treatment duration was 16 days shorter with NPWT (mean (SD) 82.8 (31.6), SMWC 98.8 (24.6); U test, p = 0.001) with 14.9 days shorter outpatient treatment (mean (SD) NPWT 68.3 (31.1), SMWC 83.2 (29.7)). The number of dressing changes per study participant was lower with NPWT (mean (SD) 35.1 (18.6), SMWC (42.9 (21.4); U test, p = 0.067). Time per dressing change was significantly lower with SMWC (mean (SD) 19.7 (12.8), NPWT (16.5 (8.2) minutes; U test, p < < 0.0001). Time for surgical debridements per study participant was 23.3 minutes shorter with NPWT (mean (SD) 20.5 (20.5), SMWC (43.8 (46.7); U test, p = 0.395). Resource use was lower for NPWT, which may be an efficient treatment alternative to SMWC for diabetic foot wounds, to be demonstrated in subsequent cost analyses. clinicaltrials.gov NCT01480362 on November 28, 2011.
Sections du résumé
BACKGROUND
BACKGROUND
Diabetic foot ulcers not only have a negative impact on patient mortality, morbidity and quality of life, but also require high resource utilization to achieve complete wound healing. The aim of this evaluation was to compare resource utilization of negative pressure wound therapy (NPWT) and standard moist wound care (SMWC) for diabetic foot wounds after amputation, surgical debridement or wound cleansing.
METHODS
METHODS
The multicenter clinical DiaFu study enrolled 368 adults with diabetic foot ulcers between December 23, 2011 and October 21, 2014. Patients were randomly assigned to NPWT and SMWC. Evaluation of direct resource use comprised inpatient and outpatient treatment time, and personnel and material for wound treatment within 16 weeks. This resource use analysis was primarily based on the per protocol population (NPWT 44; SMWC 110).
RESULTS
RESULTS
Treatment duration was 16 days shorter with NPWT (mean (SD) 82.8 (31.6), SMWC 98.8 (24.6); U test, p = 0.001) with 14.9 days shorter outpatient treatment (mean (SD) NPWT 68.3 (31.1), SMWC 83.2 (29.7)). The number of dressing changes per study participant was lower with NPWT (mean (SD) 35.1 (18.6), SMWC (42.9 (21.4); U test, p = 0.067). Time per dressing change was significantly lower with SMWC (mean (SD) 19.7 (12.8), NPWT (16.5 (8.2) minutes; U test, p < < 0.0001). Time for surgical debridements per study participant was 23.3 minutes shorter with NPWT (mean (SD) 20.5 (20.5), SMWC (43.8 (46.7); U test, p = 0.395).
CONCLUSIONS
CONCLUSIONS
Resource use was lower for NPWT, which may be an efficient treatment alternative to SMWC for diabetic foot wounds, to be demonstrated in subsequent cost analyses.
TRIAL REGISTRATION
BACKGROUND
clinicaltrials.gov NCT01480362 on November 28, 2011.
Identifiants
pubmed: 36180953
doi: 10.1186/s13047-022-00569-w
pii: 10.1186/s13047-022-00569-w
pmc: PMC9524075
doi:
Banques de données
ClinicalTrials.gov
['NCT01480362']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
72Subventions
Organisme : Statutory Health Insurance funds Germany
ID : Not applicable
Organisme : Kinetic Concepts Incorporated (KCI) (now part of 3M)
ID : Not applicable
Organisme : Smith&Nephew (S&N)
ID : Not applicable
Investigateurs
Martin Storck
(M)
Holger Lawall
(H)
Gernold Wozniak
(G)
Peter Mauckner
(P)
Dirk Hochlenert
(D)
Walter Wetzel-Roth
(W)
Klemens Sondern
(K)
Matthias Hahn
(M)
Gerhard Rothenaicher
(G)
Thomas Krönert
(T)
Karl Zink
(K)
Informations de copyright
© 2022. The Author(s).
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