Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice.
Brain
Dystonia
Epilepsy
PVALB
Selenoprotein
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
22
08
2022
revised:
19
09
2022
accepted:
22
09
2022
pubmed:
2
10
2022
medline:
2
10
2022
entrez:
1
10
2022
Statut:
ppublish
Résumé
Mice with constitutive disruption of the Selenop gene have been key to delineate the importance of selenoproteins in neurobiology. However, the phenotype of this mouse model is exquisitely dependent on selenium supply and timing of selenium supplementation. Combining biochemical, histological, and behavioral methods, we tested the hypothesis that parvalbumin-expressing interneurons in the primary somatosensory cortex and hippocampus depend on dietary selenium availability in Selenop
Identifiants
pubmed: 36182809
pii: S2213-2317(22)00262-2
doi: 10.1016/j.redox.2022.102490
pmc: PMC9526222
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102490Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest L.S. holds shares of selenOmed GmbH, a company involved in Se status assessment. All other authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.