Correlation between clinical phenotype and electromyographic parameters in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis
Clinical neurophysiology
Electromyography
Motor neuron disease
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
15
07
2022
accepted:
26
09
2022
revised:
05
09
2022
pubmed:
3
10
2022
medline:
7
1
2023
entrez:
2
10
2022
Statut:
ppublish
Résumé
Even if electromyography (EMG) is routinely used to confirm the diagnosis of amyotrophic lateral sclerosis (ALS), few studies have analysed the correlation between electrophysiological parameters and clinical characteristics of ALS. We assessed if the quantification of active denervation (AD) and chronic denervation (CD) provides clinicians with information about phenotype, disease progression and survival in ALS patients. We studied a cohort of 689 ALS patients recording the following parameters: age and site of onset, survival, MRC scale for muscle strength evaluation, burden of upper and lower motor signs as measured with specific scales (PUMNS and LMNS, respectively), ALSFRS-R, progression rate (ΔFS), MITOS and King's Staging systems (KSS). We performed EMG on 11 muscles, and calculated semiquantitative AD and CD scores for each limb, as well as for the bulbar and spinal regions. We found a positive correlation between AD and CD scores with LMNS (respectively p = 4.4 × 10 Our results confirmed that EMG examination represents not only a diagnostic instrument, but also a prognostic tool. In this context, AD seems to be a reliable predictor of disease's progression and survival while CD better describes functional disability.
Identifiants
pubmed: 36183286
doi: 10.1007/s00415-022-11404-4
pii: 10.1007/s00415-022-11404-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
511-518Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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