Methyl- rich diet ameliorates lupus-like disease in MRL/lpr mice.

Mice Animals Mice, Inbred MRL lpr Lupus Erythematosus, Systemic Proteinuria Diet Disease Models, Animal
B lymphocytes DNA methylation Diet Epigenetics Immunomodulation Methyl donors Systemic lupus erythematosus

Journal

Immunobiology
ISSN: 1878-3279
Titre abrégé: Immunobiology
Pays: Netherlands
ID NLM: 8002742

Informations de publication

Date de publication:
11 2022
Historique:
received: 16 05 2022
revised: 01 09 2022
accepted: 19 09 2022
pubmed: 3 10 2022
medline: 1 12 2022
entrez: 2 10 2022
Statut: ppublish

Résumé

Genetic susceptibility is necessary but not sufficient for systemic lupus erythematosus (SLE) to appear indicating that environmental factors are also key components in the disease onset. Aberrant DNA methylation profile positively correlates with the development of lupus-like disease in MRL/lpr mice. In the present study, we evaluate the effect of long term administration of methyl-rich diet in MRL mice. The results showed that supplemented diet decreased the levels of proteinuria and of anti-dsDNA antibodies and modulated cytokine profiles. Limited kidney failure and prevented development of skin lesions in MRL/lpr mice were another positive effects of the high-dose methyl diet. These data suggest that it is possible to modulate the disease course by altering the amount of particular dietary micronutrients and that nutrition-mediated changes in DNA methylation may have potential clinical relevance.

Identifiants

DOI: 10.1016/j.imbio.2022.152282 PMID: 36183628
pubmed: 36183628
pii: S0171-2985(22)00108-5
doi: 10.1016/j.imbio.2022.152282
pii:
doi:

Substances chimiques

anti-dsDNA autoantibody 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

152282

Informations de copyright

Copyright © 2022 Elsevier GmbH. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Kalina Nikolova-Ganeva (K)

Laboratory of Experimental Immunology, Department of Immunology, "The Stephan Angeloff" Institute of Microbiology, Bulgarian Academy of Sciences, 26 "Acad. Georgy Bontchev" Str., 1113 Sofia, Bulgaria. Electronic address: nikolova_k@microbio.bas.bg.

Silviya Bradyanova (S)

Laboratory of Experimental Immunology, Department of Immunology, "The Stephan Angeloff" Institute of Microbiology, Bulgarian Academy of Sciences, 26 "Acad. Georgy Bontchev" Str., 1113 Sofia, Bulgaria.

Iliyan Manoylov (I)

Laboratory of Experimental Immunology, Department of Immunology, "The Stephan Angeloff" Institute of Microbiology, Bulgarian Academy of Sciences, 26 "Acad. Georgy Bontchev" Str., 1113 Sofia, Bulgaria.

Gabriela Boneva (G)

Laboratory of Experimental Immunology, Department of Immunology, "The Stephan Angeloff" Institute of Microbiology, Bulgarian Academy of Sciences, 26 "Acad. Georgy Bontchev" Str., 1113 Sofia, Bulgaria.

Andrey Tchorbanov (A)

Laboratory of Experimental Immunology, Department of Immunology, "The Stephan Angeloff" Institute of Microbiology, Bulgarian Academy of Sciences, 26 "Acad. Georgy Bontchev" Str., 1113 Sofia, Bulgaria; National Institute of Immunology, 1517 Sofia, Bulgaria.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Methyl- rich diet ameliorates lupus-like...
questionsmedicales.fr › Eucaryotes › Animaux › Methyl- rich diet ameliorates lupus-like...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée MRL lpr › Methyl- rich diet ameliorates lupus-like...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Methyl- rich diet ameliorates lupus-like...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations urologiques › Protéinurie › Methyl- rich diet ameliorates lupus-like...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Methyl- rich diet ameliorates lupus-like...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Methyl- rich diet ameliorates lupus-like...