Synthesis, characterization, antioxidant potential, and cytotoxicity screening of new Cu(II) complexes with 4-(arylchalcogenyl)-1H-pyrazoles ligands.
Anticancer activity
Antioxidant activities
Copper complexes
Cytotoxicity activity
Organochalcogen
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
21
12
2021
revised:
16
09
2022
accepted:
18
09
2022
pubmed:
3
10
2022
medline:
2
11
2022
entrez:
2
10
2022
Statut:
ppublish
Résumé
Two new Cu(II) complexes based on 4-(arylchalcogenyl)-1H-pyrazoles monodentate bis(ligand) containing selenium or sulfur groups (2a and 2b) have been synthesized and characterized by IR spectroscopy, high-resolution mass spectrometry (HRMS), and by X-ray crystallography. In the effort to propose new applications for the biomedical area, we evaluated the antioxidant activity and cytotoxicity of the newly synthesized complexes. The antioxidant activity of the Cu(II) complexes (2a - 2b) were assessed through their ability to inhibit the formation of reactive species (RS) induced by sodium azide and to scavenge the synthetic radicals 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS
Identifiants
pubmed: 36183642
pii: S0162-0134(22)00302-6
doi: 10.1016/j.jinorgbio.2022.112013
pii:
doi:
Substances chimiques
Ligands
0
Antioxidants
0
Selenium
H6241UJ22B
Copper
789U1901C5
Pyrazoles
0
Sulfur
70FD1KFU70
Coordination Complexes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112013Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.