The role of colonic motility in low anterior resection syndrome.
colonic motility
low anterior resection
low anterior resection syndrome (LARS)
rectal cancer
rectosigmoid brake
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
06
2022
accepted:
29
08
2022
entrez:
3
10
2022
pubmed:
4
10
2022
medline:
4
10
2022
Statut:
epublish
Résumé
Low anterior resection syndrome (LARS) describes the symptoms and experiences of bowel dysfunction experienced by patients after rectal cancer surgery. LARS is a complex and multifactorial syndrome exacerbated by factors such as low anastomotic height, defunctioning of the colon and neorectum, and radiotherapy. There has recently been growing awareness and understanding regarding the role of colonic motility as a contributing mechanism for LARS. It is well established that rectosigmoid motility serves an important role in coordinating rectal filling and maintaining continence. Resection of the rectosigmoid may therefore contribute to LARS through altered distal colonic and neorectal motility. This review evaluates the role of colonic motility within the broader pathophysiology of LARS and outlines future directions of research needed to enable targeted therapy for specific LARS phenotypes.
Identifiants
pubmed: 36185226
doi: 10.3389/fonc.2022.975386
pmc: PMC9523793
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
975386Informations de copyright
Copyright © 2022 Varghese, Wells, Bissett, O’Grady and Keane.
Déclaration de conflit d'intérêts
GO’G, IB, and CK are members of The University of Auckland Spin-out companies: The Insides Company Ltd (GO’G, IB, CK), and Alimetry Ltd (GO’G). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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