Applications of Dexmedetomidine in Palliative and Hospice Care.
dexmedetomidine
hospice care
palliative care
sedation
Journal
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
ISSN: 1551-6776
Titre abrégé: J Pediatr Pharmacol Ther
Pays: United States
ID NLM: 101089851
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
08
2021
accepted:
10
12
2021
entrez:
3
10
2022
pubmed:
4
10
2022
medline:
4
10
2022
Statut:
ppublish
Résumé
Although the use of dexmedetomidine is currently approved by the US Food and Drug Administration in the adult population for monitored anesthesia care and sedation during mechanical ventilation, clinical experience suggests the potential application of dexmedetomidine in the palliative care arena. The medication can provide sedation with lower risk of delirium, control or minimize the adverse effects of other medications, and augment analgesia from opioids. We conducted a computerized bibliographic search of the literature regarding dexmedetomidine use for the treatment of pain and provision of sedation during palliative and hospice care in adult and pediatric patients. The objective was to provide a general descriptive account of the physiologic effects of dexmedetomidine and review its potential applications in the field of palliative and hospice care in adult and pediatric patients. The sedative and analgesic effects of dexmedetomidine have been well studied in animal and human models. Published experience from both single case reports and small case series has demonstrated the potential therapeutic applications of dexmedetomidine in palliative and hospice care. In addition to intravenous administration, case reports have demonstrated its successful use by both the intranasal and subcutaneous routes. Although these experiences have suggested its safety and efficacy, larger series and additional clinical experience with prospective comparison to other agents are needed to further define its efficacy and role in palliative and hospice care.
Identifiants
pubmed: 36186237
doi: 10.5863/1551-6776-27.7.587
pmc: PMC9514772
doi:
Types de publication
Journal Article
Langues
eng
Pagination
587-594Informations de copyright
Copyright. Pediatric Pharmacy Association. All rights reserved. For permissions, email: membership@pediatricpharmacy.org 2022.
Déclaration de conflit d'intérêts
Disclosures. The authors declare no conflicts.
Références
Pain. 1991 Sep;46(3):281-285
pubmed: 1684653
Pain Pract. 2015 Nov;15(8):E90-7
pubmed: 26205912
Anesthesiology. 2005 Aug;103(2):439-41
pubmed: 16052127
Eur Spine J. 2021 Mar;30(3):698-705
pubmed: 32696258
Am J Respir Crit Care Med. 2018 May 1;197(9):1147-1156
pubmed: 29498534
Anesthesiology. 2003 Feb;98(2):428-36
pubmed: 12552203
Anaesthesia. 1999 Dec;54(12):1136-42
pubmed: 10594409
Anesthesiology. 2000 Aug;93(2):382-94
pubmed: 10910487
Pharmacol Biochem Behav. 1992 Nov;43(3):723-7
pubmed: 1360160
Anesthesiology. 1992 Jun;76(6):948-52
pubmed: 1350889
Paediatr Anaesth. 2013 Feb;23(2):170-9
pubmed: 23043461
J Pain Symptom Manage. 2002 Jul;24(1):6-8
pubmed: 12183087
Pediatr Cardiol. 2011 Dec;32(8):1075-87
pubmed: 21909772
J Palliat Med. 2020 Nov;23(11):1515-1517
pubmed: 31944877
Int J Clin Exp Med. 2015 Aug 15;8(8):12113-34
pubmed: 26550123
Pediatr Crit Care Med. 2007 Mar;8(2):115-31
pubmed: 17273114
Anesth Analg. 2000 Mar;90(3):699-705
pubmed: 10702460
J Pain Palliat Care Pharmacother. 2006;20(2):23-7
pubmed: 16702133
Anesthesiology. 1992 Dec;77(6):1125-33
pubmed: 1361310
Pediatr Cardiol. 2013 Apr;34(4):779-85
pubmed: 23435789
Anesth Analg. 2019 Dec;129(6):1450-1453
pubmed: 31743160
Lancet. 2016 Oct 15;388(10054):1893-1902
pubmed: 27542303
Pediatr Crit Care Med. 2017 Sep;18(9):831-837
pubmed: 28598946
Psychosomatics. 2009 May-Jun;50(3):206-17
pubmed: 19567759
Am J Hosp Palliat Care. 2011 Jun;28(4):276-83
pubmed: 21131636
Anesth Analg. 2006 Jul;103(1):63-7, table of contents
pubmed: 16790627
Anesthesiology. 1989 Jul;71(1):75-9
pubmed: 2568769
Anesthesiology. 2004 Nov;101(5):1066-76
pubmed: 15505441
JAMA. 2009 Feb 4;301(5):489-99
pubmed: 19188334
J Opioid Manag. 2006 Jul-Aug;2(4):201-5
pubmed: 17319480
Anesth Analg. 2004 Jun;98(6):1658-1659
pubmed: 15155322
Anesthesiology. 1992 Dec;77(6):1134-42
pubmed: 1361311
J Palliat Med. 2019 Nov;22(11):1478-1481
pubmed: 31194614
Anesthesiology. 1980 Aug;53(2):168-9
pubmed: 7416527
Pediatr Crit Care Med. 2003 Apr;4(2):203-5
pubmed: 12749653
Anesthesiology. 1994 Dec;81(6):1527-34
pubmed: 7992922
Anaesthesia. 2001 May;56(5):408-13
pubmed: 11350323
Am J Drug Alcohol Abuse. 2015;41(5):382-91
pubmed: 26337198
Pain. 2013 Jul;154(7):1140-9
pubmed: 23706726
Anesthesiology. 2004 Mar;100(3):738-9
pubmed: 15108994
Arch Intern Med. 2000 Mar 27;160(6):786-94
pubmed: 10737278
Anesth Analg. 2004 Jan;98(1):153-158
pubmed: 14693611
BMJ Support Palliat Care. 2020 Mar;10(1):7-9
pubmed: 30636205
J Pain Palliat Care Pharmacother. 2019 Mar - Jun;33(1-2):34-41
pubmed: 31242400
J Palliat Med. 2011 Mar;14(3):371-3
pubmed: 21241196
JAMA. 2007 Dec 12;298(22):2644-53
pubmed: 18073360
Int J Geriatr Psychiatry. 2018 Nov;33(11):1428-1457
pubmed: 29278283
Palliat Care. 2015 Aug 25;9:15-8
pubmed: 26339188
J Palliat Med. 2017 Jul;20(7):779-783
pubmed: 28186850
Nature. 1993 Jul 15;364(6434):240-3
pubmed: 8391648
J Pain Res. 2017 Aug 11;10:1899-1904
pubmed: 28860845
J Pharmacol Exp Ther. 1992 Dec;263(3):1046-9
pubmed: 1361568
Anesthesiology. 2014 Oct;121(4):801-7
pubmed: 24988068
J Pain Palliat Care Pharmacother. 2010 Dec;24(4):384-6
pubmed: 21133747
J Pain Symptom Manage. 2020 Jun;59(6):e3-e5
pubmed: 32145338
J Crit Care Med (Targu Mures). 2020 Aug 11;6(3):167-174
pubmed: 32864462
Brain Res. 1985 Dec 16;359(1-2):177-82
pubmed: 2416395
Anesthesiology. 1995 Mar;82(3):620-33
pubmed: 7879930
Palliat Med. 2015 Mar;29(3):278-81
pubmed: 25467740
Burns. 2013 Jun;39(4):625-31
pubmed: 23465796
J Anaesthesiol Clin Pharmacol. 2016 Apr-Jun;32(2):240-4
pubmed: 27275057