Patient with Corticobasal Syndrome Showing Disease-Associated Biomarkers of Dementia with Lewy Bodies: A Treviso Dementia (TREDEM) Registry Case Report.
18F-FDG-PET
TREDEM
corticobasal syndrome
dementia with Lewy bodies
magnetic resonance
neurodegenerative diseases
quantitative electroencephalography
real-time quaking-induced conversion
tauopathy
α-synuclein
Journal
Journal of Alzheimer's disease reports
ISSN: 2542-4823
Titre abrégé: J Alzheimers Dis Rep
Pays: Netherlands
ID NLM: 101705500
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
04
2022
accepted:
09
07
2022
entrez:
3
10
2022
pubmed:
4
10
2022
medline:
4
10
2022
Statut:
epublish
Résumé
An 82-year-old right-handed man, a retired teacher, reported the occurrence, three years earlier, of difficulties in moving his left arm and foot, tremor in his left hand, and gestures of the left upper limb that appeared to be independent of the patient's will. We describe an unusual case of corticobasal syndrome (CBS) showing disease-associated biomarkers of dementia with Lewy bodies (DLB). Clinical, neuropsychological, imaging, and biomarker evaluations were conducted, including tau and amyloid-β levels in the cerebrospinal fluid (CSF) and a RT-QuIC assay for α-synuclein both in the CSF and olfactory mucosa (OM), as well as a QEEG assessment. The patient presented resting tremor, mild extrapyramidal hypertonus, mild bradykinesia on the left side, and severe apraxia on the left upper limb. Brain MRI showed a diffuse right hemisphere atrophy which was prominent in the posterior parietal and temporal cortices, and moderate in the frontal cortex and the precuneus area. Although in the present patient the clinical diagnosis was of probable CBS, unexpectedly positive biomarkers for DLB suggested the co-presence of multiple pathologies.
Sections du résumé
Background
UNASSIGNED
An 82-year-old right-handed man, a retired teacher, reported the occurrence, three years earlier, of difficulties in moving his left arm and foot, tremor in his left hand, and gestures of the left upper limb that appeared to be independent of the patient's will.
Objective
UNASSIGNED
We describe an unusual case of corticobasal syndrome (CBS) showing disease-associated biomarkers of dementia with Lewy bodies (DLB).
Methods
UNASSIGNED
Clinical, neuropsychological, imaging, and biomarker evaluations were conducted, including tau and amyloid-β levels in the cerebrospinal fluid (CSF) and a RT-QuIC assay for α-synuclein both in the CSF and olfactory mucosa (OM), as well as a QEEG assessment.
Results
UNASSIGNED
The patient presented resting tremor, mild extrapyramidal hypertonus, mild bradykinesia on the left side, and severe apraxia on the left upper limb. Brain MRI showed a diffuse right hemisphere atrophy which was prominent in the posterior parietal and temporal cortices, and moderate in the frontal cortex and the precuneus area.
Conclusion
UNASSIGNED
Although in the present patient the clinical diagnosis was of probable CBS, unexpectedly positive biomarkers for DLB suggested the co-presence of multiple pathologies.
Identifiants
pubmed: 36186723
doi: 10.3233/ADR-220026
pii: ADR220026
pmc: PMC9484149
doi:
Types de publication
Journal Article
Langues
eng
Pagination
431-442Informations de copyright
© 2022 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to report.
Références
Brain. 2008 Mar;131(Pt 3):690-705
pubmed: 18202105
Can J Neurol Sci. 2000 Aug;27(3):192-203
pubmed: 10975531
Tomography. 2021 Dec 18;7(4):980-989
pubmed: 34941653
Front Neurol. 2021 Sep 09;12:661130
pubmed: 34566830
Neurology. 2013 Jan 29;80(5):496-503
pubmed: 23359374
Neurol Sci. 2002 Mar;22(6):443-7
pubmed: 11976975
Neurology. 2018 Jul 17;91(3):e268-e279
pubmed: 29898972
J Alzheimers Dis. 2018;66(1):219-227
pubmed: 30282368
Int J Rehabil Res. 1984;7(2):173-81
pubmed: 6490272
J Frailty Aging. 2012;1(1):24-31
pubmed: 27092934
Arch Neurol. 1980 Jan;37(1):6-10
pubmed: 7350907
Neurol Clin Pract. 2014 Aug;4(4):304-312
pubmed: 25279254
Mov Disord. 2013 Jul;28(8):1153-5
pubmed: 23400932
Brain. 2010 Jul;133(Pt 7):2045-57
pubmed: 20584946
Brain. 2021 May 7;144(4):1118-1126
pubmed: 33855335
Trans Am Neurol Assoc. 1967;92:23-6
pubmed: 5634049
J Alzheimers Dis. 2020;77(2):689-699
pubmed: 32741832
Diagnostics (Basel). 2019 Jun 25;9(2):
pubmed: 31242587
Ital J Neurol Sci. 1987 Dec;Suppl 8:1-120
pubmed: 3330072
Neurology. 2020 Apr 28;94(17):743-755
pubmed: 32241955
Ann Clin Transl Neurol. 2019 Oct;6(10):2120-2126
pubmed: 31599499
Arch Neurol. 1968 Jan;18(1):20-33
pubmed: 5634369
Brain. 1989 Oct;112 ( Pt 5):1171-92
pubmed: 2478251
Behav Cogn Neurosci Rev. 2003 Dec;2(4):261-77
pubmed: 15006289
Neurology. 1997 May;48(5 Suppl 6):S10-6
pubmed: 9153155
Dement Neuropsychol. 2016 Oct-Dec;10(4):267-275
pubmed: 29213468
Brain Commun. 2021 Mar 22;3(2):fcab045
pubmed: 33870192
Br J Psychiatry. 1984 Sep;145:339
pubmed: 6478132
J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):806-10
pubmed: 1402972
Neurobiol Aging. 2015 Jan;36(1):434-45
pubmed: 25129239
Ital J Neurol Sci. 1987 Dec;8(6):539-48
pubmed: 3429213
J Nucl Med Technol. 2019 Mar;47(1):21-26
pubmed: 30683690
Brain. 1988 Oct;111 ( Pt 5):1173-85
pubmed: 3179688
Neurology. 1969 Jul;19(7):634-42
pubmed: 5815128
Ann Ist Super Sanita. 2016 Apr-Jun;52(2):240-8
pubmed: 27364399
Neurocase. 2021 Jun;27(3):231-237
pubmed: 34128767
Acta Neuropathol. 1999 Sep;98(3):317-22
pubmed: 10483792
Cogn Neuropsychol. 2006 Jun 1;23(4):563-82
pubmed: 21049344