Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells.
Breast cancer
Estrogen receptor α (ERα)
Hibiscus sabdariffa L.
Luminal a breast cancer cells
Triple negative breast cancer cells
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
29
04
2022
revised:
17
08
2022
accepted:
19
09
2022
entrez:
3
10
2022
pubmed:
4
10
2022
medline:
4
10
2022
Statut:
epublish
Résumé
BackgroundBreast cancer is the most frequent tumor in women. Natural substances represent an important source of innovative therapeutic solutions, eventually integrating or substituting conventional drugs and chemicals. Hibiscus sabdariffa L. is a plant of the Malvaceae family that has raised interest thanks to its anti-inflammatory, antioxidant and anticancer effects. In this work, we evaluated the antitumoral effects of an enriched fraction of Hibiscus sabdariffa L. extract (HsEF) in two human breast cancer cell lines, MCF-7(ERα +) and MDA-MB-231 (triple negative). Methods and resultsCell viability was assessed by MTT and Trypan blue assays. HsEF reduced both cell lines viability in a dose and time dependent manner and this effect results irreversible. In MCF-7 cells immunofluorescence experiments, demonstrated that HsEF induced ERα
Identifiants
pubmed: 36186735
doi: 10.1016/j.bbrep.2022.101353
pii: S2405-5808(22)00153-4
pmc: PMC9519930
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101353Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Breast Cancer Res Treat. 2012 Jan;131(1):1-15
pubmed: 21901387
Surg Oncol Clin N Am. 2018 Jan;27(1):95-120
pubmed: 29132568
Adv Protein Chem Struct Biol. 2019;116:135-170
pubmed: 31036290
Semin Oncol. 2017 Dec;44(6):377-380
pubmed: 29935898
Cancer Biother Radiopharm. 2014 Nov;29(9):368-75
pubmed: 25347557
Mol Cell Endocrinol. 2001 Jul 5;181(1-2):117-29
pubmed: 11476946
Cancer Res. 2000 Sep 15;60(18):4993-5001
pubmed: 11016617
J Food Sci. 2015 Mar;80(3):H649-58
pubmed: 25694272
J Cell Biochem. 2008 Jul 1;104(4):1254-73
pubmed: 18348185
Breast Cancer (Dove Med Press). 2019 Feb 19;11:99-110
pubmed: 30858726
Phytother Res. 2005 May;19(5):369-75
pubmed: 16106391
Chem Biodivers. 2021 Jul;18(7):e2001047
pubmed: 34000082
Breast J. 2019 Sep;25(5):967-970
pubmed: 31155832
Onco Targets Ther. 2020 Jun 11;13:5395-5405
pubmed: 32606757
J Med Assoc Thai. 2014 Aug;97 Suppl 8:S81-7
pubmed: 25518298
Asian Pac J Cancer Prev. 2015;16(16):6803-12
pubmed: 26514450
Int J Mol Sci. 2020 Aug 20;21(17):
pubmed: 32825330
Protein Cell. 2010 Feb;1(2):117-23
pubmed: 21203981
PET Clin. 2018 Jul;13(3):339-354
pubmed: 30100074
Cell Death Dis. 2013 Aug 08;4:e761
pubmed: 23928700
Prog Biophys Mol Biol. 2020 Mar;151:40-53
pubmed: 31761352
Eur J Cancer. 2005 Dec;41(18):2924-34
pubmed: 16289616
Molecules. 2019 Jul 09;24(13):
pubmed: 31323932
Breast Cancer (Auckl). 2015 Sep 01;9(Suppl 1):23-34
pubmed: 26380552
BMC Complement Altern Med. 2015 Mar 14;15:65
pubmed: 25885960
Toxicol Appl Pharmacol. 2005 Jun 15;205(3):201-12
pubmed: 15922006
Anticancer Res. 2015 Jun;35(6):3147-54
pubmed: 26026074
Nutr Cancer. 2016 Oct;68(7):1161-70
pubmed: 27618152
Breast Cancer (Dove Med Press). 2011 Oct 04;3:113-25
pubmed: 24367181
Breast Dis. 2021;40(2):51-62
pubmed: 33896802
Proc Jpn Acad Ser B Phys Biol Sci. 2009;85(1):12-36
pubmed: 19145068
Int J Clin Exp Pathol. 2014 Aug 15;7(9):5909-15
pubmed: 25337234
Cell Signal. 2013 Jan;25(1):308-18
pubmed: 23079083
Cell Physiol Biochem. 2017;44(2):778-791
pubmed: 29169152
BMC Complement Altern Med. 2019 May 6;19(1):98
pubmed: 31060537
J Antibiot (Tokyo). 2021 Oct;74(10):752-757
pubmed: 34172938
Folia Histochem Cytobiol. 2013;51(4):249-64
pubmed: 24497130
Int Immunopharmacol. 2021 Sep;98:107886
pubmed: 34153663
Mar Drugs. 2021 Apr 26;19(5):
pubmed: 33925873
Adv Drug Deliv Rev. 2021 Nov;178:113909
pubmed: 34352354
Chem Biol Interact. 2007 Jan 5;165(1):59-75
pubmed: 17145051
Front Cell Dev Biol. 2019 Jun 14;7:107
pubmed: 31259172
Mol Oncol. 2007 Sep;1(2):138-43
pubmed: 19383291
J Cell Physiol. 2003 Jul;196(1):19-41
pubmed: 12767038
Autophagy. 2015;11(5):769-84
pubmed: 25945613
Int J Mol Sci. 2018 Nov 05;19(11):
pubmed: 30400561