Cardiac magnetic resonance defines mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy.
cardiac resynchronization therapy
heart failure
implantable cardioverter defibrillator
magnetic resonance imaging
sex differences
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
07
2022
accepted:
22
08
2022
entrez:
3
10
2022
pubmed:
4
10
2022
medline:
4
10
2022
Statut:
epublish
Résumé
Mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy (CRT) are poorly understood. To use cardiac magnetic resonance (CMR) to define mechanisms of sex-based differences in outcomes after CRT and describe distinct CMR-based phenotypes of CRT candidates based on sex and non-ischemic/ischemic cardiomyopathy type. In a prospective study, sex-based differences in three short-term CRT response measures [fractional change in left ventricular end-systolic volume index 6 months after CRT (LVESVI-FC), B-type natriuretic peptide (BNP) 6 months after CRT, change in peak VO Among 200 patients, the 54 female patients (27%) pre-CRT had a smaller CMR-based LVEDVI ( CMR identifies distinct phenotypes of female CRT patients with non-ischemic and ischemic cardiomyopathy relative to male patients stratified by cardiomyopathy type. The more favorable short-term response and long-term survival outcomes in female heart failure patients with CRT were associated with lower indexed CMR-based LV volumes, decreased presence of scar associated with prior myocardial infarction and ICM, and greater CMR-based dyssynchrony with the CURE-SVD.
Sections du résumé
Background
UNASSIGNED
Mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy (CRT) are poorly understood.
Objective
UNASSIGNED
To use cardiac magnetic resonance (CMR) to define mechanisms of sex-based differences in outcomes after CRT and describe distinct CMR-based phenotypes of CRT candidates based on sex and non-ischemic/ischemic cardiomyopathy type.
Materials and methods
UNASSIGNED
In a prospective study, sex-based differences in three short-term CRT response measures [fractional change in left ventricular end-systolic volume index 6 months after CRT (LVESVI-FC), B-type natriuretic peptide (BNP) 6 months after CRT, change in peak VO
Results
UNASSIGNED
Among 200 patients, the 54 female patients (27%) pre-CRT had a smaller CMR-based LVEDVI (
Conclusion
UNASSIGNED
CMR identifies distinct phenotypes of female CRT patients with non-ischemic and ischemic cardiomyopathy relative to male patients stratified by cardiomyopathy type. The more favorable short-term response and long-term survival outcomes in female heart failure patients with CRT were associated with lower indexed CMR-based LV volumes, decreased presence of scar associated with prior myocardial infarction and ICM, and greater CMR-based dyssynchrony with the CURE-SVD.
Identifiants
pubmed: 36186999
doi: 10.3389/fcvm.2022.1007806
pmc: PMC9521735
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1007806Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL159945
Pays : United States
Informations de copyright
Copyright © 2022 Bivona, Tallavajhala, Abdi, Oomen, Gao, Malhotra, Darby, Monfredi, Mangrum, Mason, Mazimba, Salerno, Kramer, Epstein, Holmes and Bilchick.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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