An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis.

Animals Anti-Bacterial Agents Dendritic Cells Isoniazid Mice Tuberculosis Vaccines, DNA
Mycobacterium tuberculosis T cells immunotherapy intranasal route persistence stringent response tuberculosis DNA vaccines

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 18 06 2022
accepted: 31 08 2022
entrez: 3 10 2022
pubmed: 4 10 2022
medline: 5 10 2022
Statut: epublish

Résumé

Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation of persistent

Identifiants

DOI: 10.3389/fimmu.2022.972266 PMID: 36189260 PMC: PMC9523784
pubmed: 36189260
doi: 10.3389/fimmu.2022.972266
pmc: PMC9523784
doi:

Substances chimiques

Anti-Bacterial Agents 0
Vaccines, DNA 0
Isoniazid V83O1VOZ8L

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

972266

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI148710
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI143447
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI140860
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI168436
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007291
Pays : United States

Informations de copyright

Copyright © 2022 Karanika, Gordy, Neupane, Karantanos, Ruelas Castillo, Quijada, Comstock, Sandhu, Kapoor, Hui, Ayeh, Tasneen, Krug, Danchik, Wang, Schill, Markham and Karakousis.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Styliani Karanika (S)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

James T Gordy (JT)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Pranita Neupane (P)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Theodoros Karantanos (T)

Division of Hematological Malignancies, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Hospital, Baltimore, MD, United States.

Jennie Ruelas Castillo (J)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Darla Quijada (D)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Kaitlyn Comstock (K)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Avinaash K Sandhu (AK)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Aakanksha R Kapoor (AR)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Yinan Hui (Y)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Samuel K Ayeh (SK)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Rokeya Tasneen (R)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Stefanie Krug (S)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Carina Danchik (C)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Tianyin Wang (T)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Courtney Schill (C)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Richard B Markham (RB)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Petros C Karakousis (PC)

Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An intranasal stringent response vaccine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › An intranasal stringent response vaccine...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › An intranasal stringent response vaccine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides isonicotiniques › Isoniazide › An intranasal stringent response vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An intranasal stringent response vaccine...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › An intranasal stringent response vaccine...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Vaccins à base d'acide nucléique › Vaccins à ADN › An intranasal stringent response vaccine...