Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2).

Humans Pyrimidine Nucleotides Uridine Uridine Kinase / antagonists & inhibitors

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
01 11 2022
Historique:
pubmed: 4 10 2022
medline: 3 11 2022
entrez: 3 10 2022
Statut: ppublish

Résumé

Pyrimidine nucleotide biosynthesis in humans is a promising chemotherapeutic target for infectious diseases caused by RNA viruses. Because mammalian cells derive pyrimidine ribonucleotides through a combination of

Identifiants

DOI: 10.1021/acs.biochem.2c00451 PMID: 36190114
pubmed: 36190114
doi: 10.1021/acs.biochem.2c00451
doi:

Substances chimiques

Pyrimidine Nucleotides 0
UCK2 protein, human EC 2.7.1.48
Uridine WHI7HQ7H85
Uridine Kinase EC 2.7.1.48

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2261-2266

Auteurs

Siavash Mashayekh (S)

Department of Chemistry, Stanford University, Stanford, California 94305, United States.

Lee M Stunkard (LM)

Department of Chemistry, Stanford University, Stanford, California 94305, United States.

Maryline Kienle (M)

Department of Chemistry, Stanford University, Stanford, California 94305, United States.

Irimpan I Mathews (II)

Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States.
ORCID: 0000-0001-6254-3519

Chaitan Khosla (C)

Department of Chemistry, Stanford University, Stanford, California 94305, United States.
Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States.
Sarafan ChEM-H, Stanford University, Stanford, California 94305, United States.
ORCID: 0000-0001-6529-495X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-Based Prototyping of Allosteric...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Nucléotides pyrimidiques › Structure-Based Prototyping of Allosteric...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › Structure-Based Prototyping of Allosteric...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Uridine kinase › Structure-Based Prototyping of Allosteric...