Genetic and environmental factors influencing neonatal resting-state functional connectivity.
fMRI
genetic correlation
genetics
infant
twins
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
04 04 2023
04 04 2023
Historique:
received:
01
06
2021
revised:
24
08
2022
accepted:
25
08
2022
medline:
19
4
2023
pubmed:
4
10
2022
entrez:
3
10
2022
Statut:
ppublish
Résumé
Functional magnetic resonance imaging has been used to identify complex brain networks by examining the correlation of blood-oxygen-level-dependent signals between brain regions during the resting state. Many of the brain networks identified in adults are detectable at birth, but genetic and environmental influences governing connectivity within and between these networks in early infancy have yet to be explored. We investigated genetic influences on neonatal resting-state connectivity phenotypes by generating intraclass correlations and performing mixed effects modeling to estimate narrow-sense heritability on measures of within network and between-network connectivity in a large cohort of neonate twins. We also used backwards elimination regression and mixed linear modeling to identify specific demographic and medical history variables influencing within and between network connectivity in a large cohort of typically developing twins and singletons. Of the 36 connectivity phenotypes examined, only 6 showed narrow-sense heritability estimates greater than 0.10, with none being statistically significant. Demographic and obstetric history variables contributed to between- and within-network connectivity. Our results suggest that in early infancy, genetic factors minimally influence brain connectivity. However, specific demographic and medical history variables, such as gestational age at birth and maternal psychiatric history, may influence resting-state connectivity measures.
Identifiants
pubmed: 36190430
pii: 6747067
doi: 10.1093/cercor/bhac383
pmc: PMC10110449
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4829-4843Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103573
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM101219
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123716
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH064065
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA043678
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH070890
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD053000
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042988
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092335
Pays : United States
Organisme : NIDA NIH HHS
ID : R34 DA050255
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH070890
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
J Neurosci. 2012 Dec 12;32(50):18087-100
pubmed: 23238724
Fetal Diagn Ther. 2018;43(1):1-11
pubmed: 28586779
Nat Neurosci. 2011 May 29;14(7):830-2
pubmed: 21623362
J Magn Reson Imaging. 2012 Aug;36(2):344-54
pubmed: 22535702
Neuroimage. 2015 Jan 1;104:69-78
pubmed: 25281800
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1223-8
pubmed: 20133824
J Neurosci. 2015 Apr 8;35(14):5860-9
pubmed: 25855194
Radiology. 2014 Jul;272(1):29-49
pubmed: 24956047
J Am Acad Child Adolesc Psychiatry. 2011 Dec;50(12):1247-54.e2
pubmed: 22115145
Schizophr Bull. 2014 Jan;40(1):28-38
pubmed: 23960245
PLoS One. 2012;7(7):e39901
pubmed: 22848364
Neuroimage. 2016 Aug 1;136:1-9
pubmed: 27179605
Cereb Cortex. 2019 Mar 1;29(3):1139-1149
pubmed: 29420697
Dev Rev. 2018 Jun;48:113-144
pubmed: 30270962
Drug Alcohol Depend. 2019 Jul 1;200:50-58
pubmed: 31085378
Brain Res. 2008 Aug 5;1223:42-9
pubmed: 18599026
Front Behav Neurosci. 2018 Dec 19;12:319
pubmed: 30618669
PLoS One. 2012;7(5):e36222
pubmed: 22574141
Best Pract Res Clin Obstet Gynaecol. 2004 Aug;18(4):557-76
pubmed: 15279817
Neuroimage. 2018 Jul 15;175:138-149
pubmed: 29614348
Biol Psychiatry. 2009 May 1;65(9):812-8
pubmed: 19028381
Elife. 2017 Jul 26;6:
pubmed: 28745584
Front Psychol. 2018 Sep 05;9:1600
pubmed: 30233455
J Clin Psychiatry. 2019 Apr 30;80(3):
pubmed: 31090279
Cereb Cortex. 2018 Apr 1;28(4):1358-1368
pubmed: 28334317
Pediatr Res. 2009 Sep;66(3):301-5
pubmed: 19531974
Epidemiol Psychiatr Sci. 2019 Oct;28(5):521-531
pubmed: 29665879
Neuroradiology. 2021 Apr;63(4):585-591
pubmed: 32978671
Transl Psychiatry. 2020 Oct 2;10(1):335
pubmed: 33009369
Cereb Cortex. 2020 Apr 14;30(4):2099-2113
pubmed: 31711120
Schizophr Res. 2013 Jul;147(2-3):339-47
pubmed: 23706416
Cereb Cortex. 2021 Jan 1;31(1):301-311
pubmed: 32946557
Neuroscientist. 2017 Apr;23(2):169-184
pubmed: 26929236
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6790-5
pubmed: 19351894
Nat Neurosci. 2016 Jan;19(1):165-71
pubmed: 26595653
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20015-20
pubmed: 21041625
Neuroimage. 2014 Nov 15;102 Pt 2:424-34
pubmed: 25132021
Am J Epidemiol. 2013 Aug 15;178(4):543-50
pubmed: 23568591
Cereb Cortex. 2013 Mar;23(3):594-603
pubmed: 22368080
Psychol Bull. 2000 Jan;126(1):78-108
pubmed: 10668351
Front Hum Neurosci. 2014 Oct 22;8:852
pubmed: 25374531
PLoS One. 2014 May 01;9(5):e94423
pubmed: 24788455
Cereb Cortex. 2021 May 10;31(6):2834-2844
pubmed: 33429433
Curr Opin Neurobiol. 2015 Feb;30:85-91
pubmed: 25464373
Hum Brain Mapp. 2019 Nov 1;40(16):4703-4715
pubmed: 31322784
J Reprod Med. 1992 Aug;37(8):661-6
pubmed: 1432978
Gac Sanit. 2020 Jan - Feb;34(1):51-60
pubmed: 30390996
Front Neurosci. 2019 Nov 22;13:1259
pubmed: 31824254
Biol Psychiatry. 2011 May 15;69(10):967-73
pubmed: 21193174
Hum Brain Mapp. 2014 Apr;35(4):1700-9
pubmed: 23670989
J Epidemiol Community Health. 2018 May;72(5):434-441
pubmed: 29439191
Am J Obstet Gynecol. 2004 Sep;191(3):700-7
pubmed: 15467528
Front Endocrinol (Lausanne). 2014 Oct 30;5:187
pubmed: 25400620
Cereb Cortex. 2017 Dec 1;27(12):5616-5625
pubmed: 27797836
Front Psychol. 2014 Mar 26;5:183
pubmed: 24723897
Magn Reson Med. 1995 Oct;34(4):537-41
pubmed: 8524021
Hum Genet. 2015 Jul;134(7):803-8
pubmed: 25920518
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
J Child Psychol Psychiatry. 1996 Jul;37(5):569-78
pubmed: 8807437
Psychol Med. 2010 Jul;40(7):1149-58
pubmed: 19891811
J Neurosci. 2008 Nov 19;28(47):12176-82
pubmed: 19020011
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
AJNR Am J Neuroradiol. 2008 Nov;29(10):1883-9
pubmed: 18784212
Transl Psychiatry. 2015 Feb 17;5:e508
pubmed: 25689569
J Affect Disord. 2020 Dec 1;277:109-114
pubmed: 32805586
Neuroimage. 2007 Dec;38(4):696-707
pubmed: 17904385
Dev Cogn Neurosci. 2017 Jun;25:58-68
pubmed: 28223034
Neuroimage Clin. 2018 Jan 31;18:290-297
pubmed: 29876249
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
J Neurosci. 2014 Jul 2;34(27):9067-75
pubmed: 24990927
Front Neurosci. 2020 Sep 18;14:858
pubmed: 33041749
J Neurosci. 2014 Aug 20;34(34):11288-96
pubmed: 25143609
Cereb Cortex. 2017 Sep 1;27(9):4350-4360
pubmed: 27522072
Cephalalgia. 2016 Feb;36(2):139-47
pubmed: 25926619
PLoS One. 2017 Nov 17;12(11):e0188122
pubmed: 29149191
Neuroimage. 2013 Jan 1;64:240-56
pubmed: 22926292
Arch Gen Psychiatry. 2011 Dec;68(12):1267-75
pubmed: 22147844
Neuroimage. 2012 Jan 16;59(2):1404-12
pubmed: 21888983
Hum Brain Mapp. 2010 Aug;31(8):1174-82
pubmed: 20063301
Cereb Cortex. 2010 Dec;20(12):2852-62
pubmed: 20237243
Sci Rep. 2017 Jul 14;7(1):5483
pubmed: 28710394
Nat Neurosci. 2013 Sep;16(9):1348-55
pubmed: 23892552
J Am Acad Child Adolesc Psychiatry. 2007 Jan;46(1):83-91
pubmed: 17195733
Neuroimage. 2012 Mar;60(1):623-32
pubmed: 22233733
Neuroimage. 2012 Jan 2;59(1):431-8
pubmed: 21810475
Front Behav Neurosci. 2020 Feb 06;13:276
pubmed: 32116584
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16714-9
pubmed: 23012417
Cereb Cortex. 2011 Jan;21(1):145-54
pubmed: 20421249
PLoS One. 2011;6(9):e25278
pubmed: 21966479
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neurosci Lett. 2008 Aug 15;441(1):81-5
pubmed: 18584959
Neurotoxicol Teratol. 2016 Jul-Aug;56:16-25
pubmed: 27242332
PLoS One. 2013 Jul 09;8(7):e68098
pubmed: 23874510
Hum Brain Mapp. 2014 Jun;35(6):2573-81
pubmed: 24038713
Neuroimage. 2013 Dec;83:550-8
pubmed: 23747458
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Genetics. 2020 Jun;215(2):343-357
pubmed: 32291292
Hum Brain Mapp. 2020 Dec;41(17):4789-4803
pubmed: 32779835
Scand J Psychol. 2016 Oct;57(5):399-405
pubmed: 27589048
Mol Psychiatry. 2011 Feb;16(2):193-201
pubmed: 20125088
Twin Res. 2000 Dec;3(4):224-33
pubmed: 11463143
Neuroimage Clin. 2015 Mar 06;7:732-41
pubmed: 25844325
PLoS One. 2017 Dec 21;12(12):e0190248
pubmed: 29267405
Cereb Cortex. 2015 Sep;25(9):2919-28
pubmed: 24812084
Neuroimage. 2019 Nov 15;202:116073
pubmed: 31386921
J Affect Disord. 2012 Feb;136(3):1104-13
pubmed: 22134041