Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study.
Child sexual abuse
Cognitive aging
Early life adversity
Epigenetic age acceleration
Receptive language abilities
Journal
The journals of gerontology. Series B, Psychological sciences and social sciences
ISSN: 1758-5368
Titre abrégé: J Gerontol B Psychol Sci Soc Sci
Pays: United States
ID NLM: 9508483
Informations de publication
Date de publication:
01 04 2023
01 04 2023
Historique:
received:
26
04
2022
medline:
4
4
2023
pubmed:
4
10
2022
entrez:
3
10
2022
Statut:
ppublish
Résumé
Deviations from normative trajectories of receptive language abilities following early life adversity (ELA) may indicate an elevated risk for advanced cognitive aging and related morbidities. Accelerated epigenetic aging at midlife may further identify those at greatest risk for advanced cognitive aging following ELA. We examined whether accelerations in epigenetic aging at midlife can identify those individuals who demonstrated the greatest change in receptive language abilities following ELA. Data were drawn from the Female Growth and Development Study (n = 86), a 30-year prospective cohort study of females exposed to substantiated child sexual abuse (CSA), a severe ELA, and a non-CSA comparison condition. The Peabody Picture Vocabulary Test-Revised (PPVT-R) measured receptive language abilities on 6 occasions from childhood to mid-life. Interindividual differences in PPVT-R trajectories were examined in relation to CSA exposure and across 5 independent measures of epigenetic age acceleration derived from first (Horvath DNAmAge, Hannum DNAmAge) and second (GrimAge, PhenoAge, Dunedin Pace of Aging) generation epigenetic clocks. Quadratic growth models revealed that PPVT-R scores were significantly lower at age 25 for females exposed to CSA. Specifically, CSA exposed females had lower intercepts when GrimAge was accelerated and a smaller quadratic trend when PhenoAge was accelerated. ELA is associated with significant differences in development of receptive language abilities with the most pronounced differences observed for females with accelerated epigenetic ages at mid-life. These findings suggest that epigenetic age acceleration could serve as an indicator of differences in cognitive aging and portend to later adulthood cognitive functioning.
Identifiants
pubmed: 36190812
pii: 6747509
doi: 10.1093/geronb/gbac158
pmc: PMC10066744
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
585-595Subventions
Organisme : NICHD NIH HHS
ID : P50 HD089922
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD101390
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059682
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049676
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048791
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072468
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
Int J Epidemiol. 2015 Aug;44(4):1388-96
pubmed: 25617346
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Psychol Sci. 2015 Apr;26(4):433-43
pubmed: 25770099
J Exp Child Psychol. 2022 Feb;214:105305
pubmed: 34653634
J Clin Child Adolesc Psychol. 2016;45(3):361-82
pubmed: 26849071
Neurology. 2020 Feb 11;94(6):e613-e625
pubmed: 31879275
Dev Psychopathol. 2011 May;23(2):453-76
pubmed: 23786689
Acta Psychol (Amst). 1967;26(2):107-29
pubmed: 6037305
Genome Biol. 2013;14(10):R115
pubmed: 24138928
J Gerontol A Biol Sci Med Sci. 2020 Feb 14;75(3):473-480
pubmed: 31630168
BMJ. 2012 Jan 05;344:d7622
pubmed: 22223828
Psychol Bull. 2020 Sep;146(9):721-764
pubmed: 32744840
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Am J Epidemiol. 2018 Jun 1;187(6):1220-1230
pubmed: 29149257
Alzheimers Dement. 2018 Nov;14(11):1406-1415
pubmed: 29763593
Mol Psychiatry. 2021 Aug;26(8):3806-3816
pubmed: 31796892
Eur Arch Psychiatry Clin Neurosci. 2006 Apr;256(3):174-86
pubmed: 16311898
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
J Am Acad Child Adolesc Psychiatry. 2016 Jan;55(1):33-40.e3
pubmed: 26703907
Child Abuse Negl. 2020 Sep;107:104603
pubmed: 32599461
Nucleic Acids Res. 2013 Apr;41(7):e90
pubmed: 23476028
Pediatrics. 2010 Sep;126(3):e615-22
pubmed: 20696731
Elife. 2020 May 05;9:
pubmed: 32367804
Nat Genet. 2018 Aug;50(8):1112-1121
pubmed: 30038396
Aging (Albany NY). 2019 Jan 21;11(2):303-327
pubmed: 30669119
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1854-1863
pubmed: 33606025
Child Dev. 2018 Mar;89(2):638-648
pubmed: 28198006
Psychoneuroendocrinology. 2022 Mar;137:105643
pubmed: 34999481
Pediatrics. 2010 Mar;125(3):e459-66
pubmed: 20142287
Annu Rev Psychol. 2007;58:145-73
pubmed: 16903808
Dev Psychol. 2002 Jan;38(1):115-42
pubmed: 11806695
J Trauma Stress. 2013 Dec;26(6):735-43
pubmed: 24265204