Photolytic degradation of novel polymeric and monomeric brominated flame retardants: Investigation of endocrine disruption, physiological and ecotoxicological effects.
Aquatic ecotoxicology
Biomarker analysis
Brominated flame retardants
Degradation
Endocrine disruption
Lumbriculus variegatus
Journal
Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476
Informations de publication
Date de publication:
01 Dec 2022
01 Dec 2022
Historique:
received:
22
07
2022
revised:
24
09
2022
accepted:
27
09
2022
pubmed:
4
10
2022
medline:
27
10
2022
entrez:
3
10
2022
Statut:
ppublish
Résumé
Ecotoxicological effects of photolytic degradation mixtures of the two brominated flame retardants PolymericFR and Tetrabromobisphenol A-bis (2,3-dibrom-2-methyl-propyl) Ether (TBBPA-BDBMPE) have been studied in vitro and in vivo. Both substances were experimentally degraded separately by exposure to artificial UV-light and the resulting degradation mixtures from different time points during the UV-exposure were applied in ecotoxicological tests. The in vitro investigation showed no effects of the degraded flame retardants on the estrogenic and androgenic receptors via the CALUX (chemically activated luciferase gene expression) assay. Short-term exposures (up to 96 h) of Lumbriculus variegatus lead to temporary physiological reactions of the annelid. The exposure to degraded PolymericFR lead to an increased activity of Catalase, while the degradation mixture of TBBPA-BDBMPE caused increases of Glutathione-S-transferase and Acetylcholine esterase activities. Following a chronic exposure (28 d) of L. variegatus, no effects on the growth, reproduction, fragmentation and energy storage of the annelid were detected. The results indicate that the experimental degradation of the two flame retardants causes changes in their ecotoxicological potential. This might lead to acute physiological effects on aquatic annelids, which, however, do not affect the animals chronically according to our results.
Identifiants
pubmed: 36191796
pii: S0269-7491(22)01531-7
doi: 10.1016/j.envpol.2022.120317
pii:
doi:
Substances chimiques
Flame Retardants
0
Catalase
EC 1.11.1.6
Naled
PAM1AI9KU1
Acetylcholine
N9YNS0M02X
Polybrominated Biphenyls
0
Polymers
0
Ethers
0
Transferases
EC 2.-
Glutathione
GAN16C9B8O
Esterases
EC 3.1.-
Hydrocarbons, Brominated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120317Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Esther Smollich reports a relationship with DEUTSCHE ROCKWOOL GmbH & Co. KG that includes: employment. This employment has been taken up after the finalization of the experimental work reported in this article.