Corticosteroids in oncology: Use, overuse, indications, contraindications. An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of Pharmacology (SIF) multidisciplinary consensus position paper.

Humans Consensus Medical Oncology / methods Societies, Medical Contraindications Adrenal Cortex Hormones / therapeutic use Italy
Adverse events Cancer Corticosteroids Dose Glucocorticoids Indications Survival Tumour response

Journal

Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 04 08 2022
revised: 28 09 2022
accepted: 28 09 2022
pubmed: 4 10 2022
medline: 30 11 2022
entrez: 3 10 2022
Statut: ppublish

Résumé

Corticosteroids (CSs) are widely used in oncology, presenting several different indications. They are useful for induction of apoptosis in hematological neoplasms, for management of anaphylaxis and cytokine release/hypersensitivity reaction and for the symptomatic treatment of many tumour- and treatment-related complications. If the employment of CSs in the oncological setting results in several benefits for patients and satisfaction for clinicians, on the other hand, many potential adverse events (AEs), both during treatment and after withdrawal of CSs, as well as the duality of the effects of these compounds in oncology, recommend being cautious in clinical practice. To date, several gray zones remain about indications, contraindications, dose, and duration of treatment. In this article, a panel of experts provides a critical review on CSs therapy in oncology, focusing on mechanisms of action and pharmacological characteristics, current and emerging therapeutic indications/contraindications, AEs related to CSs treatment, and the impact on patient outcome.

Identifiants

DOI: 10.1016/j.critrevonc.2022.103826 PMID: 36191821
pubmed: 36191821
pii: S1040-8428(22)00250-5
doi: 10.1016/j.critrevonc.2022.103826
pii:
doi:

Substances chimiques

Adrenal Cortex Hormones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103826

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Antongiulio Faggiano (A)

Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, ENETS Center of Excellence, Sapienza University of Rome, Rome, Italy. Electronic address: antongiulio.faggiano@uniroma1.it.

Rossella Mazzilli (R)

Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, ENETS Center of Excellence, Sapienza University of Rome, Rome, Italy.

Annalisa Natalicchio (A)

Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy.

Valerio Adinolfi (V)

Endocrinology and Diabetology Unit, ASL Verbano Cusio Ossola, Domodossola, Italy.

Antonella Argentiero (A)

Medical Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.

Romano Danesi (R)

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Stella D'Oronzo (S)

Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Bari, Italy.

Stefano Fogli (S)

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Marco Gallo (M)

Endocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, Alessandria, Italy.

Dario Giuffrida (D)

Department of Oncology, Istituto Oncologico del Mediterraneo, Viagrande, Catania, Italy.

Stefania Gori (S)

Oncologia Medica, IRCCS Ospedale Don Calabria-Sacro Cuore di Negrar, Verona, Italy.

Monica Montagnani (M)

Department of Biomedical Sciences and Human Oncology - Section of Pharmacology, Medical School - University of Bari Aldo Moro, Bari, Italy.

Alberto Ragni (A)

Endocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, Alessandria, Italy.

Valerio Renzelli (V)

Diabetologist and Endocrinologist, Italian Association of Clinical Diabetologists, Italy.

Antonio Russo (A)

Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy.

Nicola Silvestris (N)

Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy.

Tindara Franchina (T)

Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy.

Enzo Tuveri (E)

Diabetology, Endocrinology and Metabolic Diseases Service, ASL-Sulcis, Italy.

Saverio Cinieri (S)

Medical Oncology Division and Breast Unit, Senatore Antonio Perrino Hospital, ASL Brindisi, Brindisi, Italy.

Annamaria Colao (A)

Endocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy; UNESCO Chair, Education for Health and Sustainable Development, Federico II University, Naples, Italy.

Francesco Giorgino (F)

Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy.

Maria Chiara Zatelli (MC)

Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Corticosteroids in oncology: Use, overuse,...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Consensus › Corticosteroids in oncology: Use, overuse,...
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Oncologie médicale › Corticosteroids in oncology: Use, overuse,...
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Sociétés › Sociétés médicales › Corticosteroids in oncology: Use, overuse,...
questionsmedicales.fr › Thérapeutique › Contre-indications › Corticosteroids in oncology: Use, overuse,...
questionsmedicales.fr › Hormones corticosurrénaliennes › Corticosteroids in oncology: Use, overuse,...
questionsmedicales.fr › Régions géographiques › Europe › Italie › Corticosteroids in oncology: Use, overuse,...