Assessing Adverse Health Effects of Long-Term Exposure to Low Levels of Ambient Air Pollution: Implementation of Causal Inference Methods.


Journal

Research report (Health Effects Institute)
ISSN: 1041-5505
Titre abrégé: Res Rep Health Eff Inst
Pays: United States
ID NLM: 8812230

Informations de publication

Date de publication:
01 2022
Historique:
entrez: 4 10 2022
pubmed: 5 10 2022
medline: 6 10 2022
Statut: ppublish

Résumé

This report provides a final summary of the principal findings and key conclusions of a study supported by an HEI grant aimed at "Assessing Adverse Health Effects of Long-Term Exposure to Low Levels of Ambient Air Pollution." It is the second and final report on this topic. The study was designed to advance four critical areas of inquiry and methods development. First, it focused on predicting short- and long-term exposures to ambient fine particulate matter (PM Considering our (1) massive study population, (2) numerous sensitivity analyses, and (3) transparent assessment of covariate balance indicating the quality of causal inference for simulating randomized experiments, we conclude that conditionally on the required assumptions for causal inference, our results collectively indicate that long-term PM Our work provides comprehensive evidence of associations between exposures to PM For the period 2000-2016, we found that all statistical approaches led to consistent results: a 10-μg/m Comparing the results from multiple and single pollutant models, we found that adjusting for the other two pollutants slightly attenuated the causal effects of PM We found evidence of a harmful causal relationship between mortality and long-term PM There is, in general, a harmful causal impact of long-term NO The ERCs of long-term O institutions, including those that support the Health Effects Institute; therefore, it may not reflect the views or policies of these parties, and no endorsement by them should be inferred. A list of abbreviations and other terms appears at the end of this volume.

Identifiants

pubmed: 36193708
pmc: PMC9530797

Substances chimiques

Air Pollutants 0
Particulate Matter 0
Ozone 66H7ZZK23N
Nitrogen Dioxide S7G510RUBH

Types de publication

Journal Article Review Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-56

Informations de copyright

© 2022 Health Effects Institute. All rights reserved.

Références

Res Rep Health Eff Inst. 2019 Nov;(200):1-51
pubmed: 31909579
Environ Health Perspect. 2019 Oct;127(10):107008
pubmed: 31638837
Science. 2018 May 4;360(6388):473
pubmed: 29724931
Sci Adv. 2020 Jul 17;6(29):eaba5692
pubmed: 32832626
Environ Int. 2020 Oct;143:105974
pubmed: 32703584
JAMA. 2019 Feb 12;321(6):602-603
pubmed: 30676631
Epidemiology. 2020 Jan;31(1):1-6
pubmed: 31430263
Res Rep Health Eff Inst. 2009 May;(140):5-114; discussion 115-36
pubmed: 19627030
Environ Sci Technol. 2019 Mar 5;53(5):2595-2611
pubmed: 30698001
Environ Health Perspect. 2015 Jun;123(6):549-56
pubmed: 25633926
Am J Epidemiol. 2005 Aug 1;162(3):279-89
pubmed: 15987725
J Epidemiol Community Health. 2012 May;66(5):468-73
pubmed: 20966448
Ann Appl Stat. 2019 Mar;13(1):520-547
pubmed: 31649797
Lancet. 2014 Mar 1;383(9919):785-95
pubmed: 24332274
Epidemiology. 2018 Sep;29(5):e45-e47
pubmed: 29912013
Biometrics. 2005 Dec;61(4):962-73
pubmed: 16401269
Environ Health Perspect. 2016 Jan;124(1):46-52
pubmed: 26038801
Proc R Soc Med. 1965 May;58:295-300
pubmed: 14283879
J Am Stat Assoc. 2020 Sep 16;1:1-12
pubmed: 33424062
Lancet. 2020 Oct 17;396(10258):1223-1249
pubmed: 33069327
Environ Health. 2014 Jan 13;13(1):2
pubmed: 24410940
J Causal Inference. 2015 Mar 1;3(1):25-40
pubmed: 26877909
Toxicol Sci. 2011 Mar;120 Suppl 1:S8-27
pubmed: 21147959
Environ Health Perspect. 2016 Mar;124(3):281-9
pubmed: 26241114
Biostatistics. 2017 Oct 1;18(4):695-710
pubmed: 28419189
Am J Epidemiol. 2014 Dec 15;180(12):1133-40
pubmed: 25399414
Ann Appl Stat. 2020 Jun;14(2):850-871
pubmed: 33649709
J Toxicol Environ Health A. 2003 Aug 22-Oct 10;66(16-19):1507-51
pubmed: 12959828
Environ Health Perspect. 2003 Dec;111(16):1861-70
pubmed: 14644658
Res Rep Health Eff Inst. 2019 Nov;(203):1-87
pubmed: 31909580
Epidemiology. 2015 Jul;26(4):536-45
pubmed: 25894856
N Engl J Med. 1993 Dec 9;329(24):1753-9
pubmed: 8179653
Environ Health Perspect. 2015 Nov;123(11):1180-6
pubmed: 26528712
Am J Epidemiol. 2017 Dec 15;186(12):1303-1309
pubmed: 29020141
N Engl J Med. 2017 Jun 29;376(26):2513-2522
pubmed: 28657878
Environ Sci Technol. 2020 Sep 15;54(18):11037-11047
pubmed: 32808786
Stat Methods Med Res. 2019 May;28(5):1365-1377
pubmed: 29415624
Environ Sci Technol. 2020 Jul 7;54(13):7879-7890
pubmed: 32491847
J Environ Health Sci. 2019;5(2):90-92
pubmed: 32104722
Am J Epidemiol. 2019 Jan 1;188(1):222-230
pubmed: 30358801
Am J Respir Crit Care Med. 2016 May 15;193(10):1134-42
pubmed: 26680605
Science. 2016 Dec 9;354(6317):1240-1241
pubmed: 27940837
Science. 2019 Mar 29;363(6434):1398-1400
pubmed: 30898845
Stat Sci. 2010 Feb 1;25(1):1-21
pubmed: 20871802
Epidemiology. 2014 May;25(3):368-78
pubmed: 24589872
Environ Int. 2019 Sep;130:104909
pubmed: 31272018
Ann Intern Med. 2017 Aug 15;167(4):268-274
pubmed: 28693043
Am J Respir Crit Care Med. 2013 Jun 1;187(11):1226-33
pubmed: 23590261
Biostatistics. 2011 Oct;12(4):610-23
pubmed: 21252080
Environ Sci Technol. 2020 Feb 4;54(3):1372-1384
pubmed: 31851499
JAMA. 2017 Dec 26;318(24):2446-2456
pubmed: 29279932
Environ Health. 2016 Feb 11;15:18
pubmed: 26864652
Epidemiology. 2000 Sep;11(5):550-60
pubmed: 10955408
J Expo Sci Environ Epidemiol. 2010 Mar;20(2):135-46
pubmed: 19277071
Biometrics. 1996 Mar;52(1):249-64
pubmed: 8934595
Stat Methods Med Res. 2017 Aug;26(4):1824-1837
pubmed: 26037527
Environ Health Perspect. 2012 May;120(5):708-14
pubmed: 22313724
Environ Res. 2018 Oct;166:677-689
pubmed: 30077140
Epidemiology. 2000 Sep;11(5):561-70
pubmed: 10955409
Biometrika. 2013;100(3):671-680
pubmed: 24795484
Epidemiology. 2017 Sep;28(5):627-634
pubmed: 28768298

Auteurs

F Dominici (F)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

A Zanobetti (A)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

J Schwartz (J)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

D Braun (D)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.

B Sabath (B)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

X Wu (X)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH