Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model.
Mice
Animals
Non-alcoholic Fatty Liver Disease
/ metabolism
Oxysterols
/ metabolism
Coffee
/ metabolism
Insulin Resistance
Caffeine
/ pharmacology
Liver
/ metabolism
Disease Models, Animal
Cholesterol
/ metabolism
Hepatitis
/ metabolism
Hepatocyte Nuclear Factors
/ metabolism
RNA, Messenger
/ metabolism
Insulins
/ metabolism
Cytochrome P450 Family 7
/ metabolism
Steroid Hydroxylases
/ metabolism
fatty liver
hepatotoxicity
inflammation
insulin resistance
oxysterols
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
pubmed:
5
10
2022
medline:
3
11
2022
entrez:
4
10
2022
Statut:
ppublish
Résumé
Oxysterol 7α-hydroxylase (CYP7B1) controls the levels of intracellular regulatory oxysterols generated by the "acidic pathway" of cholesterol metabolism. Previously, we demonstrated that an inability to upregulate CYP7B1 in the setting of insulin resistance leads to the accumulation of cholesterol metabolites such as (
Identifiants
pubmed: 36193897
doi: 10.1152/ajpgi.00179.2022
pmc: PMC9639758
doi:
Substances chimiques
Oxysterols
0
Coffee
0
Caffeine
3G6A5W338E
Cholesterol
97C5T2UQ7J
Hepatocyte Nuclear Factors
0
RNA, Messenger
0
Insulins
0
Cyp7b1 protein, mouse
EC 1.14.14.29
Cytochrome P450 Family 7
EC 1.14.14.23
Steroid Hydroxylases
EC 1.14.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
G488-G500Subventions
Organisme : BLRD VA
ID : IS1 BX004777
Pays : United States
Organisme : BLRD VA
ID : I01 BX000197
Pays : United States
Organisme : BLRD VA
ID : I01 BX004033
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA026629
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004477
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104893
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK057543
Pays : United States
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