Multilayer Scaling of a Biomimetic Microfluidic Oxygenator.
Journal
ASAIO journal (American Society for Artificial Internal Organs : 1992)
ISSN: 1538-943X
Titre abrégé: ASAIO J
Pays: United States
ID NLM: 9204109
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
entrez:
4
10
2022
pubmed:
5
10
2022
medline:
7
10
2022
Statut:
ppublish
Résumé
Extracorporeal membrane oxygenation (ECMO) has been advancing rapidly due to a combination of rising rates of acute and chronic lung diseases as well as significant improvements in the safety and efficacy of this therapeutic modality. However, the complexity of the ECMO blood circuit, and challenges with regard to clotting and bleeding, remain as barriers to further expansion of the technology. Recent advances in microfluidic fabrication techniques, devices, and systems present an opportunity to develop new solutions stemming from the ability to precisely maintain critical dimensions such as gas transfer membrane thickness and blood channel geometries, and to control levels of fluid shear within narrow ranges throughout the cartridge. Here, we present a physiologically inspired multilayer microfluidic oxygenator device that mimics physiologic blood flow patterns not only within individual layers but throughout a stacked device. Multiple layers of this microchannel device are integrated with a three-dimensional physiologically inspired distribution manifold that ensures smooth flow throughout the entire stacked device, including the critical entry and exit regions. We then demonstrate blood flows up to 200 ml/min in a multilayer device, with oxygen transfer rates capable of saturating venous blood, the highest of any microfluidic oxygenator, and a maximum blood flow rate of 480 ml/min in an eight-layer device, higher than any yet reported in a microfluidic device. Hemocompatibility and large animal studies utilizing these prototype devices are planned. Supplemental Visual Abstract, http://links.lww.com/ASAIO/A769.
Identifiants
pubmed: 36194101
doi: 10.1097/MAT.0000000000001647
pii: 00002480-202210000-00015
pmc: PMC9521578
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1312-1319Informations de copyright
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO.
Déclaration de conflit d'intérêts
Disclosure: The authors have no conflicts of interest to report.
Références
Patel SB, Kress JP: Sedation and analgesia in the mechanically ventilated patient. Am J Respir Crit Care Med 185: 486–497, 2012.
Fan E, Brodie D, Slutsky AS: Mechanical Ventilation during Extracorporeal Support for Acute Respiratory Distress Syndrome. For Now, a Necessary Evil. Am J Respir Crit Care Med 195: 1137–1139, 2017.
Palanzo D, Qiu F, Baer L, Clark JB, Myers JL, Undar A: Evolution of the extracorporeal life support circuitry. Artif Organs 34: 869–873, 2010.
Schoberer M, Arens J, Lohr A, et al.: Fifty years of work on the artificial placenta: milestones in the history of extracorporeal support of the premature newborn. Artif Organs 36: 512–516, 2012.
Gray BW, Haft JW, Hirsch JC, Annich GM, Hirschl RB, Bartlett RH: Extracorporeal life support: experience with 2,000 patients. ASAIO J 61: 2–7, 2015.
Brodie D, Bacchetta M: Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med 365: 1905–1914, 2011.
Bartlett RH: Esperanza: the first neonatal ECMO patient. ASAIO J 63: 832–843, 2017.
Cornish JD, Carter JM, Gerstmann DR, Null DM Jr: Extracorporeal membrane oxygenation as a means of stabilizing and transporting high risk neonates. ASAIO Trans 37: 564–568, 1991.
Greenough A, Agha M, Smith APR: Extracorporeal membrane oxygenation for neonates. In: Neonatology: A Practical Approach to Neonatal Diseases. New York City, NY, Springer, 2012.
Neff LP, Cannon JW, Stewart IJ, et al.: Extracorporeal organ support following trauma: the dawn of a new era in combat casualty critical care. J Trauma Acute Care Surg 75(2 Suppl 2): S120–8; discussion S128, 2013.
Cannon JW, Mason PE, Batchinsky AI: Past and present role of extracorporeal membrane oxygenation in combat casualty care: how far will we go? J Trauma Acute Care Surg 84(6S Suppl 1): S63–S68, 2018.
Noah MA, Peek GJ, Finney SJ, et al.: Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA 306: 1659–1668, 2011.
Tavazzi G, Pellegrini C, Maurelli M, et al.: Myocardial localization of coronavirus in COVID-19 cardiogenic shock. Eur J Heart Fail 22: 911–915, 2020.
Lang Y, Zheng Y, Li T: The treatment of extracorporeal organ support for critical ill patients with coronavirus disease 2019: a brief perspective from the front line. Artificial Organs 45:189–190, 2020.
Federspiel W, Henchir K: Lung, artificial: basic principles and current applications. In: Encyclopedia of Biomaterials and Biomedical Engineering, 2nd ed. Boca Raton, FL, CRC Press, 2008; Volume 4.
Kniazeva T, Epshteyn AA, Hsiao JC, et al.: Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device. Lab Chip 12: 1686–1695, 2012.
Gimbel AA, Hsiao JC, Kim ES, et al.: A high gas transfer efficiency microfluidic oxygenator for extracorporeal respiratory assist applications in critical care medicine. Artif Organs 45: E247–E264, 2021.
Potkay JA: The promise of microfluidic artificial lungs. Lab Chip 14: 4122–4138, 2014.
Wagner G, Kaesler A, Steinseifer U, Schmitz-Rode T, Arens J: Comment on ‘the promise of microfluidic artificial lungs’ by J. A. Potkay, Lab Chip , 2014, 14, 4122-4138. Lab Chip 2016. doi:10.1039/c5lc01508a.
doi: 10.1039/c5lc01508a
Potkay JA: Reply to the ‘Comment on “The promise of microfluidic artificial lungs”’ by G. Wagner, A. Kaesler, U. Steinseifer, T. Schmitz-Rode and J. Arens, Lab Chip, 2016, 16. Lab Chip 16: 1274–1277, 2016.
Reyes DR, van Heeren H, Guha S, et al.: Accelerating innovation and commercialization through standardization of microfluidic-based medical devices. Lab Chip 21: 9–21, 2021.
Kaazempur-Mofrad MR, Krebs NJ, Vacanti JP, Borenstein JT: A MEMS-based renal replacement system. Proc. 2004 Sensors and Actuators Conf., Hilton Head Is., June 2004. Cleveland OH, Transducers Research Foundation, 2004.
Burgess KA, Hu HH, Wagner WR, Federspiel WJ: Towards microfabricated biohybrid artificial lung modules for chronic respiratory support. Biomed Microdevices 11: 117–127, 2009.
Kung MC, Lee JK, Kung HH, Mockros LF: Microchannel technologies for artificial lungs: (2) screen-filled wide rectangular channels. ASAIO J 54: 383–389, 2008.
Potkay JA: The promise of microfluidic artificial lungs. Lab Chip 14: 4122–4138, 2014.
Hoganson DM, Pryor HI 2nd, Bassett EK, Spool ID, Vacanti JP: Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform. Lab Chip 11: 700–707, 2011.
Dabaghi M, Saraei N, Fusch G, et al.: Microfluidic blood oxygenators with integrated hollow chambers for enhanced air exchange from all four sides. J Memb Sci 596: 117741, 2020.
Mohamed MGA, Kumar H, Wang Z, Martin N, Mills B, Kim K: Rapid and inexpensive fabrication of multi-depth microfluidic device using high-resolution LCD stereolithographic 3D printing. J Manuf Mater Proces 3: 26, 2019.
Santos J, Vedula EM, Lai W, et al.: Toward development of a higher flow rate hemocompatible biomimetic microfluidic blood oxygenator. Micromachines (Basel) 12: 888, 2021.
Matharoo H, Dabaghi M, Rochow N, et al.: Steel reinforced composite silicone membranes and its integration to microfluidic oxygenators for high performance gas exchange. Biomicrofluidics 12: 014107, 2018.