Assessing the efficacy and safety of Unani pharmacopoeial formulations in dermatophytosis (quba) - a randomized controlled trial.
Quba
Qurs-e-Asfar
Rogan-e-Narjeel
Unani formulations
dermatophytosis
Journal
Drug metabolism and personalized therapy
ISSN: 2363-8915
Titre abrégé: Drug Metab Pers Ther
Pays: Germany
ID NLM: 101653409
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
14
04
2022
accepted:
30
05
2022
medline:
7
6
2023
pubmed:
5
10
2022
entrez:
4
10
2022
Statut:
epublish
Résumé
The recent trends of rising unresponsive cases of dermatophytosis to conventional therapies pose a challenge in clinical practice. Unani medicine offers effective treatment for dermatophytosis. This study aimed to evaluate the efficacy and safety of the Unani herbo-mineral preparations Qurs-e-Asfar (QA) and Rogan-e-Narjeel (RN) in dermatophytosis. This was a randomized, active-controlled and open-label clinical study. The participants diagnosed with dermatophytosis (n=78) randomized into treatment group (n=40) receiving oral QA (778 mg twice a day) and topical RN and control group (n=38) receiving oral Itraconazole (100 mg/day) and topical Terbinafine hydrochloride (1%) for 6 weeks. We found post-treatment improvement in itching by 86.3% vs. 78% (treatment vs. control group), erythema by 96.4% vs. 94.3%, scaling by 93% vs. 92.2% and peripheral raised margins by 82.3% vs. 81%. Furthermore, this study showed that the differences in the mean Total Signs and Symptoms Score (TSSS) and positive KOH mount were clinically and statistically significant (p<0.05) in both the groups. On comparing inter group, the differences in mean TSSS (p=0.07) and positive KOH mount (p=0.717) were found statistically insignificant. This study concludes that the formulations QA and RN were effective and safe in the treatment of dermatophytosis.
Identifiants
pubmed: 36194619
pii: dmpt-2022-0125
doi: 10.1515/dmpt-2022-0125
doi:
Substances chimiques
Antifungal Agents
0
Terbinafine
G7RIW8S0XP
Banques de données
CTRI
['CTRI/2020/04/024765']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
169-177Informations de copyright
© 2022 Walter de Gruyter GmbH, Berlin/Boston.
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