Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development.
PTM mitigation
antibody characterization
antibody engineering
clinical development
fentanyl
humanized antibody
mAb
manufacturability
opioid use disorder
synthetic opioids
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
30 Nov 2022
30 Nov 2022
Historique:
pubmed:
5
10
2022
medline:
15
12
2022
entrez:
4
10
2022
Statut:
ppublish
Résumé
Innovative therapies to complement current treatments are needed to curb the growing incidence of fatal overdoses related to synthetic opioids. Murine and chimeric monoclonal antibodies (mAb) specific for fentanyl and its analogs have demonstrated pre-clinical efficacy in preventing and reversing drug-induced toxicity in rodent models. However, mAb-based therapeutics require extensive engineering as well as
Identifiants
pubmed: 36194773
doi: 10.1080/21645515.2022.2122507
pmc: PMC9746415
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Monoclonal, Humanized
0
Complement System Proteins
9007-36-7
Fentanyl
UF599785JZ
Narcotic Antagonists
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2122507Subventions
Organisme : NIDA NIH HHS
ID : U01 DA051658
Pays : United States
Organisme : NIDA NIH HHS
ID : UG3 DA057850
Pays : United States
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