The influence of somatic maturity on the relationship between the triglyceride/high-density lipoprotein ratio and vascular health in children and adolescents with dyslipidemia.
Journal
American journal of human biology : the official journal of the Human Biology Council
ISSN: 1520-6300
Titre abrégé: Am J Hum Biol
Pays: United States
ID NLM: 8915029
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
19
09
2022
received:
24
06
2022
accepted:
20
09
2022
pmc-release:
01
02
2024
pubmed:
6
10
2022
medline:
16
2
2023
entrez:
5
10
2022
Statut:
ppublish
Résumé
Both the triglyceride to HDL cholesterol (TG/HDL) ratio and timing of pubertal maturation have been identified as independent contributors to the development of atherosclerosis. The purpose of our study was to determine the relationship between the TG/HDL ratio and measures of vascular health in children and adolescents with dyslipidemia stratified by somatic maturity. We hypothesized that somatic maturity would have a significant interaction with TG/HDL ratio and vascular health. This was a longitudinal analysis of 120 children and adolescents (age 8-14 years) with dyslipidemia recruited from a pediatric preventive cardiology clinic. At baseline and each follow-up visit, a non-fasting serum lipid panel was collected and vascular health (carotid artery intima--media thickness, pulse wave velocity, augmentation index) was assessed. Peak height velocity (PHV) was calculated at each visit, and participants were stratified into groups by maturity offset (pre-PHV, mid-PHV, post-PHV). A mixed model design permitted baseline and follow-up visits to be classified as discrete data points. Of the n = 235 data points (pre-PHV = 23%, mid-PHV = 19%, and post-PHV = 58%), we identified no significant interaction between TG/HDL ratio, maturity offset, and measures of vascular structure or function. There was also no significant relationship found between TG/HDL and maturity group. Within the mid-pubertal group, there was weak relationship found between TG/HDL and augmentation index. Despite the well-described relationship between early pubertal maturation and development of cardiovascular risk factors in adulthood, we found that vascular damage resulting from an elevated TG/HDL ratio is not independently associated with somatic maturity.
Identifiants
pubmed: 36196910
doi: 10.1002/ajhb.23815
pmc: PMC9931626
mid: NIHMS1838356
doi:
Substances chimiques
Triglycerides
0
Lipoproteins, HDL
0
Cholesterol, HDL
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23815Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL159325
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
Eur J Endocrinol. 2013 Dec 21;170(2):173-80
pubmed: 24165018
Pediatrics. 2011 Dec;128 Suppl 5:S213-56
pubmed: 22084329
Arterioscler Thromb. 1992 Dec;12(12):1496-502
pubmed: 1450181
Cholesterol. 2012;2012:794252
pubmed: 22811895
Atherosclerosis. 2015 Jan;238(1):9-16
pubmed: 25461733
Pediatrics. 2013 Apr;131(4):e1082-90
pubmed: 23460684
Am J Clin Nutr. 2000 Nov;72(5 Suppl):1307S-1315S
pubmed: 11063473
Nutr Metab Cardiovasc Dis. 2015 May;25(5):489-94
pubmed: 25813687
Circulation. 2022 Feb 22;145(8):e153-e639
pubmed: 35078371
Int J Obes (Lond). 2013 Aug;37(8):1036-43
pubmed: 23164700
Pediatr Cardiol. 2019 Apr;40(4):805-812
pubmed: 30759268
Sci Rep. 2019 Jul 30;9(1):11037
pubmed: 31363129
Hypertension. 2013 Sep;62(3):550-6
pubmed: 23817494
Prev Med. 1993 Mar;22(2):154-66
pubmed: 8483855
Med Sci Sports Exerc. 2015 Aug;47(8):1755-64
pubmed: 25423445
Int J Sports Med. 2002 May;23 Suppl 1:S39-43
pubmed: 12012261
Lect Sci Basis Med. 1953;1:308-63
pubmed: 13184740
Food Nutr Bull. 2006 Dec;27(4 Suppl Growth Standard):S244-56
pubmed: 17361661
J Adolesc Health. 2002 Dec;31(6 Suppl):192-200
pubmed: 12470915
Arch Pediatr Adolesc Med. 2009 Aug;163(8):709-15
pubmed: 19652102
Am J Cardiol. 2004 Jul 15;94(2):219-22
pubmed: 15246907
J Pediatr. 2003 Jun;142(6):643-6
pubmed: 12838192
J Lipid Res. 1993 Oct;34(10):1687-97
pubmed: 8245719
Sci Rep. 2015 Jun 18;5:11208
pubmed: 26084728
Arch Dis Child. 1969 Jun;44(235):291-303
pubmed: 5785179
Clinics (Sao Paulo). 2008 Aug;63(4):427-32
pubmed: 18719750
J Am Soc Echocardiogr. 2010 Jan;23(1):58-63
pubmed: 19962856
J Hum Hypertens. 2014 Aug;28(8):475-81
pubmed: 24430704
Arteriosclerosis. 1989 Jan-Feb;9(1 Suppl):I19-32
pubmed: 2912430
J Pediatr. 2016 Mar;170:199-205
pubmed: 26706233
Clin Chem. 2005 Jul;51(7):1192-200
pubmed: 15890892
Nutr Metab Cardiovasc Dis. 2014 Jul;24(7):737-43
pubmed: 24656140
Front Endocrinol (Lausanne). 2019 Aug 27;10:591
pubmed: 31507538
Pediatr Pathol Mol Med. 2002 Mar-Apr;21(2):213-37
pubmed: 11942537
Lancet Diabetes Endocrinol. 2016 Dec;4(12):1017-1024
pubmed: 27815089
JAMA. 2016 Aug 9;316(6):589-91
pubmed: 27532913
Obesity (Silver Spring). 2008 Jul;16(7):1672-9
pubmed: 18451769
Acta Paediatr. 2014 Aug;103(8):e349-53
pubmed: 24796207
Arch Dis Child. 1970 Feb;45(239):13-23
pubmed: 5440182
Circulation. 1990 Aug;82(2):495-506
pubmed: 2372896
JAMA. 2013 Nov 20;310(19):2061-8
pubmed: 24240933
Pediatrics. 1998 Aug;102(2 Pt 3):507-11
pubmed: 9685454
J Pediatr. 2011 Jan;158(1):44-50
pubmed: 20801459
Diabetes Care. 2012 Jan;35(1):158-62
pubmed: 22040842
Circulation. 1997 Oct 21;96(8):2520-5
pubmed: 9355888
Circ Cardiovasc Imaging. 2010 Jan;3(1):8-14
pubmed: 19920030
MMWR Morb Mortal Wkly Rep. 1999 Aug 6;48(30):649-56
pubmed: 10488780
Med Sci Sports Exerc. 2002 Apr;34(4):689-94
pubmed: 11932580
Diabetologia. 2005 Aug;48(8):1445-53
pubmed: 15971059
Arterioscler Thromb. 1992 Mar;12(3):332-40
pubmed: 1547192