Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
25 Oct 2022
25 Oct 2022
Historique:
pubmed:
6
10
2022
medline:
27
10
2022
entrez:
5
10
2022
Statut:
epublish
Résumé
The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further
Substances chimiques
Antiviral Agents
0
Ligands
0
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM