Hypothalamic astrocytes control systemic glucose metabolism and energy balance.

Animals Astrocytes / metabolism Energy Metabolism / physiology Glucose / metabolism Glutamic Acid / metabolism Hypothalamus / metabolism Mice Obesity / metabolism Paraventricular Hypothalamic Nucleus / metabolism
PVN astrocyte energy homeostasis glucose metabolism glutamate obesity

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
04 Oct 2022
Historique:
received: 23 02 2022
revised: 23 06 2022
accepted: 02 09 2022
entrez: 5 10 2022
pubmed: 6 10 2022
medline: 12 10 2022
Statut: ppublish

Résumé

The hypothalamus is key in the control of energy balance. However, strategies targeting hypothalamic neurons have failed to provide viable options to treat most metabolic diseases. Conversely, the role of astrocytes in systemic metabolic control has remained largely unexplored. Here, we show that obesity promotes anatomically restricted remodeling of hypothalamic astrocyte activity. In the paraventricular nucleus (PVN) of the hypothalamus, chemogenetic manipulation of astrocytes results in bidirectional control of neighboring neuron activity, autonomic outflow, glucose metabolism, and energy balance. This process recruits a mechanism involving the astrocytic control of ambient glutamate levels, which becomes defective in obesity. Positive or negative chemogenetic manipulation of PVN astrocyte Ca

Identifiants

DOI: 10.1016/j.cmet.2022.09.002 PMID: 36198294 PMC: PMC9615252
pubmed: 36198294
pii: S1550-4131(22)00392-8
doi: 10.1016/j.cmet.2022.09.002
pmc: PMC9615252
mid: NIHMS1836286
pii:
doi:

Substances chimiques

Glutamic Acid 3KX376GY7L
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1532-1547.e6

Subventions

Organisme : NHLBI NIH HHS
ID : F32 HL158172
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090948
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL162575
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS094640
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Daniela Herrera Moro Chao (D)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France. Electronic address: herrerad@umn.edu.

Matthew K Kirchner (MK)

Neuroscience Institute, Georgia State University, Atlanta, GA 30303, USA; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA 30302, USA.

Cuong Pham (C)

Institute of Biology Paris Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, Sorbonne Universite, Paris 75005, France.

Ewout Foppen (E)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Raphael G P Denis (RGP)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France; Institut Cochin, Université Paris Cité, INSERM U1016, CNRS UMR 8104, 75014 Paris, France.

Julien Castel (J)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Chloe Morel (C)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Enrica Montalban (E)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Rim Hassouna (R)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Linh-Chi Bui (LC)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Justine Renault (J)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Christine Mouffle (C)

Institute of Biology Paris Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, Sorbonne Universite, Paris 75005, France.

Cristina García-Cáceres (C)

Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Neuherberg, 85764, Germany; Division of Metabolic Diseases, Technische Universität München, Munich, 80333, Germany; Medizinische Klinik and Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany.

Matthias H Tschöp (MH)

Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Neuherberg, 85764, Germany; Division of Metabolic Diseases, Technische Universität München, Munich, 80333, Germany.

Dongdong Li (D)

Institute of Biology Paris Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, Sorbonne Universite, Paris 75005, France.

Claire Martin (C)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.

Javier E Stern (JE)

Neuroscience Institute, Georgia State University, Atlanta, GA 30303, USA; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA 30302, USA.

Serge H Luquet (SH)

Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France. Electronic address: serge.luquet@u-paris.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Hypothalamic astrocytes control systemic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Hypothalamus antérieur › Noyau paraventriculaire de l'hypothalamus › Hypothalamic astrocytes control systemic...