Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis.
Animals
Carcinogenesis
/ pathology
Carcinoma, Hepatocellular
/ pathology
Cell Proliferation
Collagen Type I
/ metabolism
Discoidin Domain Receptor 1
/ metabolism
Disease Progression
Hepatic Stellate Cells
/ metabolism
Hepatocyte Growth Factor
/ metabolism
Hepatocytes
Humans
Liver Cirrhosis
/ complications
Liver Neoplasms
/ pathology
Mice
Myofibroblasts
/ pathology
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
26
04
2021
accepted:
30
08
2022
pubmed:
6
10
2022
medline:
15
10
2022
entrez:
5
10
2022
Statut:
ppublish
Résumé
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide, develops almost exclusively in patients with chronic liver disease and advanced fibrosis
Identifiants
pubmed: 36198802
doi: 10.1038/s41586-022-05289-6
pii: 10.1038/s41586-022-05289-6
pmc: PMC9949942
mid: NIHMS1867159
doi:
Substances chimiques
Collagen Type I
0
Hepatocyte Growth Factor
67256-21-7
Discoidin Domain Receptor 1
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
356-365Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK128955
Pays : United States
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 219542/Z/19/Z
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA190844
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116620
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA228483
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK132710
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211794
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA274295
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA262424
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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