Assessment of cerebrovascular function in patients with sickle cell disease using transfer function analysis.


Journal

Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800

Informations de publication

Date de publication:
10 2022
Historique:
revised: 29 08 2022
received: 04 07 2022
accepted: 01 09 2022
entrez: 6 10 2022
pubmed: 7 10 2022
medline: 12 10 2022
Statut: ppublish

Résumé

In patients with sickle cell disease (SCD), the delivery of oxygen to the brain is compromised by anemia, abnormal rheology, and steno-occlusive vascular disease. Successful compensation depends on an increase in oxygen supply such as that provided by an increase in cerebral blood flow (CBF). We used magnetic resonance imaging to provide a high-resolution assessment of the ability of SCD patients to respond to a vasoactive stimulus in middle, anterior, and posterior cerebral artery territories for both white and gray matter. Cerebrovascular reactivity (CVR) was measured as the blood oxygen level dependent signal (a surrogate for CBF) response to an increase in the end tidal partial pressure of CO

Identifiants

pubmed: 36200271
doi: 10.14814/phy2.15472
pmc: PMC9535348
doi:

Substances chimiques

Carbon Dioxide 142M471B3J
Oxygen S88TT14065

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e15472

Informations de copyright

© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

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Auteurs

Ece Su Sayin (ES)

Department of Physiology, University of Toronto, Toronto, Canada.
Departments of Anaesthesia and Pain Management, University Health Network, Toronto, Canada.

Olivia Sobczyk (O)

Department of Physiology, University of Toronto, Toronto, Canada.
Departments of Anaesthesia and Pain Management, University Health Network, Toronto, Canada.
Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, Canada.

Julien Poublanc (J)

Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, Canada.

David J Mikulis (DJ)

Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, Canada.
Institute of Medical Sciences, University of Toronto, Toronto, Canada.

Joseph A Fisher (JA)

Department of Physiology, University of Toronto, Toronto, Canada.
Departments of Anaesthesia and Pain Management, University Health Network, Toronto, Canada.

Kevin H M Kuo (KHM)

Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

James Duffin (J)

Department of Physiology, University of Toronto, Toronto, Canada.
Departments of Anaesthesia and Pain Management, University Health Network, Toronto, Canada.

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