Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
27 10 2022
27 10 2022
Historique:
pubmed:
7
10
2022
medline:
29
10
2022
entrez:
6
10
2022
Statut:
ppublish
Résumé
Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated DNA double strand break repair, has been proposed as an attractive target for the treatment of BRCA deficient and other DNA repair pathway defective cancers. As previously reported, we recently identified the first selective small molecule Polθ in vitro probe,
Identifiants
pubmed: 36200480
doi: 10.1021/acs.jmedchem.2c01142
doi:
Substances chimiques
Ligands
0
Poly(ADP-ribose) Polymerase Inhibitors
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13879-13891Commentaires et corrections
Type : ErratumIn