The Role of Cartilage Stem/Progenitor Cells in Cartilage Repair in Osteoarthritis.

Cartilage stem cell cartilage cartilage progenitor cell osteoarthritis regenerative therapy stem cell therapy

Journal

Current stem cell research & therapy
ISSN: 2212-3946
Titre abrégé: Curr Stem Cell Res Ther
Pays: United Arab Emirates
ID NLM: 101272517

Informations de publication

Date de publication:
2023
Historique:
received: 13 07 2022
revised: 28 08 2022
accepted: 09 09 2022
medline: 5 6 2023
pubmed: 7 10 2022
entrez: 6 10 2022
Statut: ppublish

Résumé

Osteoarthritis (OA) is a degenerative joint disease characterized by the loss of cartilage, which seriously affects the quality of patient's life and may even cause permanent sequelae. The treatment of OA is diversified, mostly limited to relieving clinical symptoms. Less invasive treatments that can cure OA are still lacking. With the rise of tissue-cell engineering, stem cell therapy has gradually aroused great interest in treating OA. Cartilage stem/progenitor cells (CSPCs), a type of stem cell found on the surface of articular cartilage, have many similarities with mesenchymal stem cells (MSCs). These cells can be isolated and cultured from animals and humans and exist in articular cartilage over the body, such as the knee joint, patellofemoral joint, and temporomandibular joint. Due to their strong proliferative and chondrogenic differentiation abilities, CSPCs may contribute a lot to cartilage regeneration and repair in OA. We will provide an overview of the biological characteristics of CSPCs and their role in OA in combination with the research progress. Despite some existing limitations, CSPCs still offer an innovative idea for OA treatment with great advantages.

Identifiants

pubmed: 36201278
pii: CSCR-EPUB-126808
doi: 10.2174/1574888X17666221006113739
pmc: PMC10278241
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

892-903

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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Auteurs

Ning Hu (N)

State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.

Jingwen Qiu (J)

State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.

Bo Xu (B)

Department of Stomatology, Panzhihua Central Hospital, Panzhihua City, Sichuan Province, China.

Shunhao Zhang (S)

State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.

Zijian Guo (Z)

State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China.

Jing Xie (J)

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Medical Affairs, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Wenbin Yang (W)

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Medical Affairs, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

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