Chemoenzymatic surface decoration of Nisin-shelled nanoemulsions: Novel targeted drug-nanocarriers for cancer applications.

Humans Azides Nisin / pharmacology Doxorubicin / pharmacology Neoplasms Immunoglobulin G
Drug delivery Nanoemulsion Nisin Ultrasonication

Journal

Ultrasonics sonochemistry
ISSN: 1873-2828
Titre abrégé: Ultrason Sonochem
Pays: Netherlands
ID NLM: 9433356

Informations de publication

Date de publication:
Nov 2022
Historique:
received: 03 03 2022
revised: 04 08 2022
accepted: 05 08 2022
pubmed: 7 10 2022
medline: 25 11 2022
entrez: 6 10 2022
Statut: ppublish

Résumé

Nisin, a peptide used as a natural food preservative, is employed in this work for the development of a novel nanocarrier system. Stable and uniform nisin-shelled nanoemulsions (NSNE) with a diameter of 100 ± 20 nm were successfully prepared using 20 kHz flow-through ultrasonication technique. The NSNE showed limited toxicity, high bactericidal activity and high drug loading capacity (EE 65 % w/w). In addition, the nisin shell was exploited for the site-specific attachment of a recombinantly produced cancer targeting ligand (αHER2

Identifiants

DOI: 10.1016/j.ultsonch.2022.106183 PMID: 36201933 PMC: PMC9554623
pubmed: 36201933
pii: S1350-4177(22)00279-6
doi: 10.1016/j.ultsonch.2022.106183
pmc: PMC9554623
pii:
doi:

Substances chimiques

Azides 0
Nisin 1414-45-5
Doxorubicin 80168379AG
Immunoglobulin G 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106183

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Rania A Hashad (RA)

NanoTheranostics Laboratory, Australian Center for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia; NanoBiotechnology Laboratory, Australian Center for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, AinShamsUniversity, Cairo, Egypt.

Ritu Singla (R)

School of Chemistry, University of Melbourne, VIC 3010, Australia.

Sukhvir Kaur Bhangu (S)

School of Chemistry, University of Melbourne, VIC 3010, Australia.

Edwina Jap (E)

NanoTheranostics Laboratory, Australian Center for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.

Haiyan Zhu (H)

School of Chemistry, University of Melbourne, VIC 3010, Australia; School of Science, RMIT University, Melbourne, VIC 3000, Australia.

Anton Y Peleg (AY)

Department of Infectious Diseases, The Alfred Hospital & Monash University, VIC 3004, Australia.

Luke Blakeway (L)

Department of Infectious Diseases, The Alfred Hospital & Monash University, VIC 3004, Australia.

Christoph E Hagemeyer (CE)

NanoBiotechnology Laboratory, Australian Center for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.

Francesca Cavalieri (F)

School of Science, RMIT University, Melbourne, VIC 3000, Australia.

Muthupandian Ashokkumar (M)

School of Chemistry, University of Melbourne, VIC 3010, Australia.

Karen Alt (K)

NanoTheranostics Laboratory, Australian Center for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia. Electronic address: karen.alt@monash.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chemoenzymatic surface decoration of...
questionsmedicales.fr › Composés chimiques organiques › Azotures › Chemoenzymatic surface decoration of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Bactériocines › Nisine › Chemoenzymatic surface decoration of...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Chemoenzymatic surface decoration of...
questionsmedicales.fr › Tumeurs › Chemoenzymatic surface decoration of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Chemoenzymatic surface decoration of...