Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma.
BIOT-NFL, the NFL-TBS.40–63 peptide coupled to the biotin
BIOT-NFL-peptide-nanofibers
CAC, critical aggregation concentration
DMEM, dulbecco's modified eagle medium
FAM-NFL, the NFL-TBS.40–63 peptide coupled to 5-carboxy-fluorescein
Glioblastoma
Gold nanoparticles
NFL-SCR, the scrambled NFL-TBS.40–63 peptide (with the same amino acids as the NFL-peptide but in a different order)
NFL-TBS.40-63 peptide
NFL-peptide, neurofilament light subunit derived 24 amino acid tubulin-binding site peptide NFL-TBS.40–63
SDS, sodium dodecyl sulfate
Self-assembly
TEM, transmission electron microscopy
Targeted drug delivery
UPLC, ultra-performance liquid chromatography system
XRS, x-ray scattering
aCSF, artificial cerebrospinal fluid
nude-NFL, the NFL-TBS.40–63 peptide with no labeling
Journal
International journal of pharmaceutics: X
ISSN: 2590-1567
Titre abrégé: Int J Pharm X
Pays: Netherlands
ID NLM: 101753452
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
29
08
2022
accepted:
30
08
2022
entrez:
7
10
2022
pubmed:
8
10
2022
medline:
8
10
2022
Statut:
epublish
Résumé
NFL-TBS.40-63 peptide is a recently discovered peptide derived from the light neurofilament chain (NFL). In this study, we demonstrated that the Biotinylated-NFL-peptide (BIOT-NFL) can spontaneously self-assemble into well-organized nanofibers (approximately 5 nm width and several micrometers in length) in several solutions, whereas the typical self-assembly was not systematically observed from other peptides with or without coupling. The critical aggregation concentration that allows the BIOT-NFL-peptide to aggregate and auto associate was determined at 10
Identifiants
pubmed: 36204592
doi: 10.1016/j.ijpx.2022.100128
pii: S2590-1567(22)00017-2
pmc: PMC9529584
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100128Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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