Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels.

Humans Cystic Fibrosis Transmembrane Conductance Regulator / metabolism Epithelial Sodium Channels Molecular Docking Simulation Cations / metabolism
CFTR inhibitors ENaC In silico modelling Off-target effects Orai1 Store-operated calcium entry

Journal

Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720

Informations de publication

Date de publication:
02 2023
Historique:
received: 22 07 2022
accepted: 03 10 2022
revised: 28 09 2022
pubmed: 8 10 2022
medline: 21 1 2023
entrez: 7 10 2022
Statut: ppublish

Résumé

The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na

Identifiants

DOI: 10.1007/s00424-022-02758-9 PMID: 36205782 PMC: PMC9849171
pubmed: 36205782
doi: 10.1007/s00424-022-02758-9
pii: 10.1007/s00424-022-02758-9
pmc: PMC9849171
doi:

Substances chimiques

Cystic Fibrosis Transmembrane Conductance Regulator 126880-72-6
N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide 0
Epithelial Sodium Channels 0
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone 0
Cations 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

167-179

Informations de copyright

© 2022. The Author(s).

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Auteurs

JinHeng Lin (J)

Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.

Sean M Gettings (SM)

School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.

Khaoula Talbi (K)

Physiological Institute, University of Regensburg, 93053, Regensburg, Germany.

Rainer Schreiber (R)

Physiological Institute, University of Regensburg, 93053, Regensburg, Germany.

Michael J Taggart (MJ)

Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Matthias Preller (M)

Department of Natural Sciences/Institute for Functional Gene Analytics, Structural Biology Group, Bonn-Rhein-Sieg University of Applied Sciences, 53359, Rheinbach, Germany.

Karl Kunzelmann (K)

Physiological Institute, University of Regensburg, 93053, Regensburg, Germany.

Mike Althaus (M)

School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Department of Natural Sciences /Institute for Functional Gene Analytics, Ion Transport Physiology Group, Bonn-Rhein-Sieg University of Applied Sciences, 53359, Rheinbach, Germany.

Michael A Gray (MA)

Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. m.a.gray@newcastle.ac.uk.
ORCID: 0000-0002-6774-6283

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacological inhibitors of the cystic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Protéines associées à la multirésistance aux médicaments › Protéine CFTR › Pharmacological inhibitors of the cystic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux sodiques › Canaux sodium épithéliaux › Pharmacological inhibitors of the cystic...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Pharmacological inhibitors of the cystic...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Pharmacological inhibitors of the cystic...