The impact of cerebral vasomotor reactivity on cerebrovascular diseases and cognitive impairment.
Cerebral vasoreactivity
Cerebrovascular disorders
Cognitive dysfunction
Stroke
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
04
07
2022
accepted:
19
09
2022
pubmed:
8
10
2022
medline:
13
10
2022
entrez:
7
10
2022
Statut:
ppublish
Résumé
The regulation of cerebral blood flow (CBF) is a complex and tightly controlled function ensuring delivery of oxygen and nutrients and removal of metabolic wastes from brain tissue. Cerebral vasoreactivity (CVR) refers to the ability of the nervous system to regulate CBF according to metabolic demands or changes in the microenvironment. This can be assessed through a variety of nuclear medicine and imaging techniques and protocols. Several studies have investigated the association of CVR with physiological and pathological conditions, with particular reference to the relationship with cognitive impairment and cerebrovascular disorders (CVD). A better understanding of the interaction between CVR and cognitive dysfunction in chronic and particularly acute CVD could help improving treatment and rehabilitation strategies in these patients. In this paper, we reviewed current knowledge on CVR alterations in the context of acute and chronic CVD and cognitive dysfunction. Alterations in CVR and hemodynamics have been described in patients with both neurodegenerative and vascular cognitive impairment, and the severity of these alterations seems to correlate with CVR derailment. Furthermore, an increased risk of cognitive impairment progression has been associated with alterations in CVR parameters and hemodynamics. Few studies have investigated these associations in acute cerebrovascular disorders and the results are inconsistent; thus, further research on this topic is encouraged.
Identifiants
pubmed: 36205784
doi: 10.1007/s00702-022-02546-w
pii: 10.1007/s00702-022-02546-w
pmc: PMC9550758
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1321-1330Informations de copyright
© 2022. The Author(s).
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