Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.
Journal
Pancreas
ISSN: 1536-4828
Titre abrégé: Pancreas
Pays: United States
ID NLM: 8608542
Informations de publication
Date de publication:
01 07 2022
01 07 2022
Historique:
entrez:
7
10
2022
pubmed:
8
10
2022
medline:
12
10
2022
Statut:
ppublish
Résumé
The association between acute pancreatitis (AP) and diabetes mellitus (DM) has long been established, with the initial descriptions of AP patients presenting with DM after a bout of AP published in the 1940s and 50s. However, the potential mechanisms involved, particularly those components related to the immune system, have not been well defined. The Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM) study is a multicenter clinical study designed to understand the frequency and phenotype of DM developing after AP. This article describes one objective of the DREAM study: to determine the immunologic mechanisms of DM after AP, including the contribution of β-cell autoimmunity. This component of the study will assess the presence of islet autoimmunity, as well as the magnitude and kinetics of the innate and adaptive immune response at enrollment and during longitudinal follow-up after 1 or more episodes of AP. Finally, DREAM will evaluate the relationship between immune features, DM development, and pancreatitis etiology and severity.
Identifiants
pubmed: 36206462
doi: 10.1097/MPA.0000000000002076
pii: 00006676-202207000-00004
pmc: PMC9555855
mid: NIHMS1817323
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
580-585Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK127403
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127392
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127367
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127395
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK108314
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127388
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127377
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127382
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127400
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127378
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127404
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127384
Pays : United States
Informations de copyright
Copyright © 2022 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.
Déclaration de conflit d'intérêts
J.A.H. consults for aTyr Pharma. F.G.S.T. has received consulting fees from Sanofi, Eli Lilly, and AstraZeneca and research support from Dompé. G.I.P. has <5% equity with Ariel Precision Medicine, has consulted with Nestle, and receives research funds from Abbvie. M.D.B. receives research support from Viacyte and Dexcom and has participated on an advisory board with Insulet. C.S. participates on an advisory board for Vertex Pharmaceuticals. The rest of the authors declare no conflict of interest.
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